Rs910873

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melanoma
is asnp
is mentioned by
dbSNPrs910873
hapmaprs910873
hgdprs910873
ensemblrs910873
gopubmedrs910873
scholarrs910873
googlers910873
pharmgkbrs910873
hgvbaseg2prs910873
medrefsnprs910873
23andMers910873
SNP Nexus

GenePIGU
Chromosome20
Orientationplus
Position32635432
GenotypeEffect
rs910873(A;A)3x increased risk of melanoma
rs910873(A;G)1.7x increased risk of melanoma
rs910873(G;G)normal


Genotypes Magnitude Summary
Rs910873(A;A) 44 3x increased risk of melanoma
Rs910873(A;G) 33 1.7x increased risk of melanoma
Rs910873(G;G) 00 normal
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

[PMID 18488026] 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120 combined P less than 1 10-15. The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

? (A;A) (A;G) (G;G)
GWAS
SNP rs910873
PubMedID [PMID 18488026]
Condition Melanoma
Gene CDC91L1
Risk Allele T
pValue 1.00E-015
OR 1.75
95% CI 1.53-2.01


Related to MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 7; CMM7 according to omim 612263. See also


PharmGKBPA161925569
Name
AnnotationSNP on chromosome 20 is highly associated with melanoma risk. rs910873 (and, through LD, rs1885120) seems to be related to early onset.
GenePIGU
Featue
EvidencePubMed ID:18488026
Drugs
DiseasesMelanoma
Curation LevelCurated
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