Rs8050136
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs8050136 |
| hapmap | rs8050136 |
| hgdp | rs8050136 |
| ensembl | rs8050136 |
| gopubmed | rs8050136 |
| scholar | rs8050136 |
| rs8050136 | |
| pharmgkb | rs8050136 |
| hgvbaseg2p | rs8050136 |
| medrefsnp | rs8050136 |
| 23andMe | rs8050136 |
| SNP Nexus |
| Gene | FTO |
| Chromosome | 16 |
| Orientation | plus |
| Position | 52373775 |
| Genotype | Effect |
|---|---|
| rs8050136(A;A) | 1.4x increased risk for T2D in some populations |
| rs8050136(A;C) | 1.2x increased risk for T2D in some populations |
| rs8050136(C;C) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs8050136(A;A) | 1.41.4 | 1.4x increased risk for T2D in some populations |
| Rs8050136(A;C) | 1.21.2 | 1.2x increased risk for T2D in some populations |
| Rs8050136(C;C) | 00 | normal |
This SNP is in a linkage block in the FTO gene with rs1121980; see rs1121980 for the association of this block with early onset obesity since it showed the strongest association.[PMID 18159244]
This SNP did not show any association with obesity, type-2 diabetes or any other related traits in a study of 3,210 Chinese subjects. Furthermore, the minor allele frequency was much lower in Chinese populations compared to populations of European descent.[PMID 17959933]
However, a more recent study of 4,189 Chinese Han subjects combined with a meta-analysis of published studies concluded that rs8050136(A) was associated with both increased risk for type-2 diabetes and obesity.[PMID 20057365]
[PMID 19053021] rs8050136 associated with increased food intake, but not of impaired energy expenditure.
| ? | (A;A) (A;C) (C;C) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs8050136 |
| PubMedID | [PMID 17463249] |
| Condition | Type 2 diabetes |
| Gene | FTO |
| Risk Allele | A |
| pValue | 1.00E-012 |
| OR | 1.17 |
| 95% CI | 1.12-1.22 |
[PMID 19303973] RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study.
[PMID 19056611] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
| GWAS snp | |
|---|---|
| PMID | [PMID 19079260] |
| Trait | Body mass index |
| Title | Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity |
| Risk Allele | A |
| P-val | 1E-47 |
| Odds Ratio | 8.04 [6.96-9.12] % SD |
| GWAS snp | |
|---|---|
| PMID | [PMID 18372903] |
| Trait | Type 2 diabetes |
| Title | Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes |
| Risk Allele | A |
| P-val | 0.0000069999999999999999 |
| Odds Ratio | 1.15 [1.09-1.22] |
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
[PMID 19543202] FTO Genotype Is Associated With Exercise Training-induced Changes in Body Composition
| GWAS snp | |
|---|---|
| PMID | [PMID 17463248] |
| Trait | Type 2 diabetes |
| Title | A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants |
| Risk Allele | A |
| P-val | 1E-12 |
| Odds Ratio | 1.17 [1.12-1.22] |
[PMID 19584900] Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
[PMID 19798072] FTO Genotype and the Weight Loss Benefits of Moderate Intensity Exercise
| PharmGKB | PA162191333 |
| Name | |
| Annotation | rs8050136 is associated with susceptibility to Type 2 Diabetes. This association was identified in a UK case-control study and was replicated in another UK case-control cohort. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17463249 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 2 |
| Curation Level | Curated |
[PMID 20061430] Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
[PMID 19833889] Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study
