Rs7977109

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is asnp
is mentioned by
dbSNPrs7977109
hapmaprs7977109
hgdprs7977109
ensemblrs7977109
gopubmedrs7977109
scholarrs7977109
googlers7977109
pharmgkbrs7977109
hgvbaseg2prs7977109
medrefsnprs7977109
23andMers7977109
SNP Nexus

GeneNOS1
Chromosome12
Orientationplus
Position116214723
GenotypeEffect
rs7977109(A;A)*
rs7977109(A;G)*
rs7977109(G;G)*


After scanning a region of chromosome 12 previously linked to restless legs syndrome in ~900 patients, German investigators found SNPs within the NOS1 gene to be most associated with the syndrome. SNP rs7977109 yielded an odds ratio of 0.76 (CI: 0.64 -0.90, p=-.002). The risk allele is said to be defined in Supplementary materials available online, but they aren't. Furthermore, the significant association seen for this SNP and one other (rs693534) are in opposite directions in the explorative versus the replication populations.[PMID 18058820]

? (A;A) (A;G) (G;G)