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Rs7688672

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.8 If Taiwanese, you might be ~3x more likely to develop gout
(G;G) 0
Make rs7688672(A;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position81148295
GenePRKG2
is asnp
is mentioned by
dbSNPrs7688672
ebirs7688672
Exacrs7688672
PheGenIrs7688672
nextbiors7688672
hapmaprs7688672
1000 genomesrs7688672
hgdprs7688672
ensemblrs7688672
gopubmedrs7688672
geneviewrs7688672
scholarrs7688672
googlers7688672
pharmgkbrs7688672
gwascentralrs7688672
openSNPrs7688672
23andMers7688672
23andMe allrs7688672
SNP Nexus

SNPshotrs7688672
SNPdbers7688672
MSV3drs7688672
GWAS Ctlgrs7688672
GMAF0.4605
Max Magnitude2.8
? (A;A) (A;G) (G;G) 28

Two SNPs in the cGMP-dependent protein kinase II (cGK II) PRKG2 gene, rs7688672 and rs6837293, were found to be associated in 148 matched Taiwanese case:control subjects with gout disease using a recessive model after adjustment of hyperuricemia (odds ratio 2.72, CI: 1.13-6.54).[PMID 18678579]

Note that this was a relatively small study and since the original 2009 publication cited there has not been a publication confirming or replicating the finding. A 2015 paper of Han Chinese (listed below) found no significant association between rs7688672 on it's own and gout sensitivity, however, a haplotype including rs7688672 and a linked SNP had a weak association.


[PMID 25688884] Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and Gout Susceptibility of Han Population in Northern China