From SNPedia
rs763361, also known as Gly307Ser, is a SNP in the immune response
CD226 gene. The
rs763361(T) allele (in dbSNP orientation) encodes the Ser.
Based on multiple studies (by one group) now totaling over 2,000 patients, the rs763361(T) allele is associated with increased risk for multiple autoimmune diseases, including type-1 diabetes (p = 3 x 10e-9), multiple sclerosis (p = 4 x 10e-4), and possibly rheumatoid arthritis (p = 0.017). Based on tag SNP analysis, the authors conclude that this SNP could be the causal variant.[PMID 18971939]
[PMID 18987646] Tested in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10 296 unrelated controls, SNP rs763361 was associated with disease risk (p = 5.4 x 10e-8)
| ? | (C;C) (C;T) (T;T) |
|---|
 |
[PMID 19624611] The CD226 gene in susceptibility of type 1 diabetes
| PharmGKB | PA162356634 |
| Name | |
| Annotation | GWAS Results: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes (Initial Sample Size: 1,963 cases, 2,938 controls; Replication Sample Size: 4,000 cases, 5,000 controls, 2,997 trios; Risk Allele: rs763361-A). |
| Gene | CD226 |
| Featue | |
| Evidence | PubMed ID:17554260; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Diabetes Mellitus, Diabetes Mellitus, Type 1 |
| Curation Level | Non-Curated |
[PMID 19951419] Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
