Rs7566605

From SNPedia

rs7566605 was initially reported as being associated in at least 4 independent populations as being associated with obesity however replications are inconsistent, and a recent (2009) large meta-analysis comprising 34 studies (and over 70,000 subjects) has concluded that there is no evidence for overall association of the rs7566605 polymorphism with obesity.[PMID 19851442] See also: [PMID 16614226] Poster

At least one population has since been reported in which this association was not seen. [PMID 17218508] Furthermore, a study of 18,000 Danish subjects also failed to find any direct role for this SNP in the development of obesity, except that among physically inactive subjects, (C)-allele carriers tended to have a higher body mass index (by O.5 kg/m2) than (G)-allele carriers.[PMID 18682847]

On the other hand, a report has also been published indicating that obese children who are rs7566605(C;C) homozygotes find it harder to lose weight in clinical intervention programs than (C;G) heterozygotes or (G;G) homozygotes, which supports the association of SNP rs7566605 with obesity. [PMID 18003761]

[PMID 18570692] associated with the prevalence of hypercholesterolemia, but not with obesity, in Japanese American women. In Japanese American women, rs7566605(C;C) individuals had a 0.43-fold decreased risk (CI: 0.24 - 0.80) for hypercholesterolemia compared with the (G;G) homozygotes after adjustment for age and other factors. No significant differences in BMI, waist girth and percentage body fat according to the genotype in each of the four groups, which was divided by population and sex. The rs7566605(C;C) genotype is suggested to be a protective genetic factor against the progression of hypercholesterolemia on a high-fat diet, especially in Japanese female subjects.

[PMID 18839134] rs9939609 and rs7566605 linked to obesity

[PMID 19105843] underlies variation in subcutaneous adiposity in young adult women and suppresses the positive effects of resistance training on men.

[PMID 19197259] does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors

[PMID 19197262] rs7566605 is not associated with obesity-related traits and lipids in the ~2,00 person European Youth Heart Study.

[PMID 19197259] rs7566605 near the INSIG2 gene does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors in a study of ~7,000 German adults.

[PMID 19263810] Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents

[PMID 19360016] INSIG2 SNPs Associated With Obesity and Glucose Homeostasis Traits in Hispanics: The IRAS Family Study

[PMID 19399648] Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants

[PMID 19523229] The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts

[PMID 19772594] Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations

[PMID 20028541] A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans

[PMID 20045156] Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age