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Rs7454108

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Higher risk of type-1 diabetes
Orientationplus
is asnp
is mentioned by
dbSNPrs7454108
PheGenIrs7454108
nextbiors7454108
hapmaprs7454108
1000 genomesrs7454108
hgdprs7454108
ensemblrs7454108
gopubmedrs7454108
geneviewrs7454108
scholarrs7454108
googlers7454108
pharmgkbrs7454108
gwascentralrs7454108
openSNPrs7454108
23andMers7454108
23andMe allrs7454108
SNP Nexus

SNPshotrs7454108
SNPdbers7454108
MSV3drs7454108
Chromosome6
Orientationplus
GMAF0.09826
Position32713706
ReferenceGRCh38 38.1/141
Max Magnitude1.5
Geno Mag Summary
(C;C) 1.5 Homozygous for HLA-DQ8 haplotype
(C;T) 1.5 Single HLA-DQ8 haplotype
(T;T) 0 common in complete genomics
? (C;C) (C;T) (T;T) 28
[PMID 18694972OA-icon.png] People with the human leukocyte antigen (HLA) genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (more simply known as "DR3/4-DQ8") are at the highest risk of developing type-1 diabetes.

The rs2040410(A) allele is associated with DRB1*0301, and the rs7454108(C) allele is associated with DQB1*0302 (and thus DQ8).

Instead of more traditional antibody-based tests, two SNPs (rs2040410 and rs7454108) can be used to identify the presence or absence of the DR3/4-DQ8 genotype and thus the highest-risk heterozygous genotype associated with type-1 diabetes. For users of Promethease, this is determined via Gs121.

Neighborrs2858331
Distance206
[PMID 15747258OA-icon.png] A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.


[PMID 18509540OA-icon.png] Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.


[PMID 19143815OA-icon.png] MHC fine mapping of human type 1 diabetes using the T1DGC data.


[PMID 19143817OA-icon.png] Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex.


[PMID 19455305OA-icon.png] No association of multiple type 2 diabetes loci with type 1 diabetes.


[PMID 22511809] Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.