Rs7454108

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dbSNPrs7454108
hapmaprs7454108
hgdprs7454108
ensemblrs7454108
gopubmedrs7454108
scholarrs7454108
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pharmgkbrs7454108
hgvbaseg2prs7454108
medrefsnprs7454108
23andMers7454108
SNP Nexus

Chromosome6
Orientationplus
Position32789460
GenotypeEffect
rs7454108(C;C)*?
rs7454108(C;T)*?
rs7454108(T;T)*?


[PMID 18694972] People with the human leukocyte antigen (HLA) genotype DRB1*0301-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302 (more simply known as "DR3/4-DQ8") are at the highest risk of developing type-1 diabetes.

The rs2040410(A) allele is associated with DRB1*0301, and the rs7454108(C) allele is associated with DQB1*0302.

Instead of more traditional antibody-based tests, two SNPs (rs2040410 and rs7454108) can be used to identify the presence or absence of the DR3/4-DQ8 genotype and thus the highest-risk heterozygous genotype associated with type-1 diabetes. For users of Promethease, this is determined via Gs121.

? (C;C) (C;T) (T;T)
Neighborrs2858331
Distance206