Rs743777

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is asnp
is mentioned by
dbSNPrs743777
hapmaprs743777
hgdprs743777
ensemblrs743777
gopubmedrs743777
scholarrs743777
googlers743777
pharmgkbrs743777
hgvbaseg2prs743777
medrefsnprs743777
23andMers743777
SNP Nexus

Chromosome22
Orientationplus
Position37551607
ReferenceGRCh37 37.1/131
GenotypeEffect
rs743777(A;A)1.7x risk
rs743777(A;G)1.1x risk
rs743777(G;G)normal


Genotypes Magnitude Summary
Rs743777(A;A) 00 1.7x risk
Rs743777(A;G) 1.1x risk
Rs743777(G;G) normal
? (A;A) (A;G) (G;G) 28
rs743777 has been reported in a large study to be associated with rheumatoid arthritis.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.09 (CI 0.97-1.24), and for homozygotes, 1.72 (CI 1.40-2.11). [PMID 17554300]

GWAS
SNP rs743777
PubMedID [PMID 17554300]
Condition Rheumatoid arthritis
Gene NR
Risk Allele G
pValue 1.00E-006
OR 1.09
95% CI 0.97-1.24


PharmGKBPA162356657
Name
AnnotationGWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,860 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs743777-G). This variant is associated with rheumatoid arthritis.
GeneIL2RB
Featue
EvidencePubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
Drugs
DiseasesArthritis, Rheumatoid
Curation LevelNon-Curated