rs743777 has been reported in a large study to be associated with rheumatoid arthritis.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.09 (CI 0.97-1.24), and for homozygotes, 1.72 (CI 1.40-2.11). [PMID 17554300
]
| GWAS snp
|
| PMID
|
[PMID 21653640]
|
| Trait
|
|
| Title
|
Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.
|
| Risk Allele
|
G
|
| P-val
|
0.000002
|
| Odds Ratio
|
1.1900 [1.10-1.30]
|
| GWAS snp
|
| PMID
|
[PMID 21829393]
|
| Trait
|
|
| Title
|
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
| Risk Allele
|
G
|
| P-val
|
0.000002
|
| Odds Ratio
|
1.1000 [NR]
|
[PMID 18625055] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.
[PMID 18794857] Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
[PMID 20017963] Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.
[PMID 20426808] AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.
[PMID 20728947] A novel galectin-1 and interleukin 2 receptor beta haplotype is associated with autoimmune myasthenia gravis.
[PMID 22328738] Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
]
