From SNPedia
The ancestral allele is C. The
rs7412(T) allele, also known as Arg176Cys, generally indicates the presence of an ApoE2 allele; see the
ApoE page for a full discussion of the ApoE alleles and their association with
Alzheimer's disease.
Another SNP related to ApoE is rs429358.
In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic olanzapine, carriers of a rs7412(C) allele were more likely to gain significant weight compared to rs7412(T;T) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs5092 and rs4765623, were also significantly associated with weight profiles in these patients.[PMID 17199131]
- related to HYPERLIPOPROTEINEMIA, TYPE III, ASSOCIATED WITH APOE2-FUKUOKA according to omim 107741.0019
| PharmGKB | PA162355842 |
| Name | APOE: 4075C>T, p.Arg158Cys, (g.8041C>T, c.526C>T, p.Arg176Cys in dbSNP build 130) |
| Annotation | Risk or phenotype-associated allele: ApoE E4 allele (rs429358 C, rs7412 C) (130Arg, 176Arg). Phenotype: Increased incidence of chronic plaque psoriasis and guttate psoriasis, but no difference in response of psoriasis to the drug acitretin. Study size: 306 cases, 137 controls. Study population/ethnicity: Patients with chronic plaque psoriasis (n = 212), guttate psoriasis (n = 94). Significance metric(s): p =0.008 Type of association: CO; GN |
| Gene | APOC1, APOE |
| Featue | |
| Evidence | PubMed ID:16433808 |
| Drugs | acitretin |
| Diseases | Psoriasis |
| Curation Level | Curated |
| ? | (C;C) (C;T) (T;T) |
|---|
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