Rs688034

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs688034
PheGenI	rs688034
nextbio	rs688034
hapmap	rs688034
1000 genomes	rs688034
hgdp	rs688034
ensembl	rs688034
gopubmed	rs688034
geneview	rs688034
scholar	rs688034
google	rs688034
pharmgkb	rs688034
gwascentral	rs688034
openSNP	rs688034
23andMe	rs688034
23andMe all	rs688034
SNP Nexus
SNPshot	rs688034
SNPdbe	rs688034
MSV3d	rs688034

Gene

SEZ6L

Chromosome

22

Orientation

plus

GMAF

0.1603

Position

26689635

Reference

GRCh37 37.1/131

Max Magnitude

2

Geno	Mag	Summary
(C;C)	0	normal
(C;T)		1.1x risk
(T;T)	2	1.6x risk

?	(C;C) (C;T) (T;T)	28

rs688034 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.11 (CI 0.98-1.25), and for homozygotes, 1.62 (CI 1.34-1.95). [PMID 17554300]

GWAS
SNP	rs688034
PubMedID	[PMID 17554300]
Condition	Coronary disease
Gene	NR
Risk Allele	T
pValue	4.00E-006
OR	1.11
95% CI	0.99-1.25

[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.

[PMID 20017983] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

GET Evidence
rs688034
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.140625
summary