|| 1.1x risk higher risk for coronary artery disease
|| 1.6x risk
|?|| (C;C) (C;T) (T;T) ||28|
has been reported in a large study to be associated with heart disease
, in particular, coronary artery disease
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.11 (CI 0.98-1.25), and for homozygotes, 1.62 (CI 1.34-1.95). [PMID 17554300]
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 20017983] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
|| Insufficiently evaluated pathogenic