Rs6836703

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Orientationplus
Geno Mag Summary
(A;A) 1.34x increased risk for azoospermia in males
(A;G) 1.34x increased risk for azoospermia in males
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome4
Position76108994
GeneART3
is asnp
is mentioned by
dbSNPrs6836703
PheGenIrs6836703
nextbiors6836703
hapmaprs6836703
1000 genomesrs6836703
hgdprs6836703
ensemblrs6836703
gopubmedrs6836703
geneviewrs6836703
scholarrs6836703
googlers6836703
pharmgkbrs6836703
gwascentralrs6836703
openSNPrs6836703
23andMers6836703
23andMe allrs6836703
SNP Nexus

SNPshotrs6836703
SNPdbers6836703
MSV3drs6836703
GMAF0.2383
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs6836703 is one of several tightly linked SNPs in the ART3 gene found in a study of ~400 infertile males to be associated with somewhat increased risk of the type of male infertility known as non-obstructive azoospermia. The odds ratio reported for rs6836703(A) carriers is 1.34 (CI:1.11–1.63, p=0.0025).[PMID 18266473OA-icon.png]

An almost equivalent ART3 SNP is rs14773, for which it's also the minor allele ((C) in this case) reported to represent increased risk for azoospermia and which is in tight linkage with rs6836703. Two other ART3 SNPs, rs11097230 and rs17001385, also achieved statistical significance, yet for them, the minor alleles were associated with reduced risk for azoospermia.[PMID 18266473OA-icon.png]