Rs680244
| Orientation | minus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs680244 |
| PheGenI | rs680244 |
| nextbio | rs680244 |
| hapmap | rs680244 |
| 1000 genomes | rs680244 |
| hgdp | rs680244 |
| ensembl | rs680244 |
| gopubmed | rs680244 |
| geneview | rs680244 |
| scholar | rs680244 |
| rs680244 | |
| pharmgkb | rs680244 |
| gwascentral | rs680244 |
| openSNP | rs680244 |
| 23andMe | rs680244 |
| 23andMe all | rs680244 |
| SNP Nexus | |
| SNPshot | rs680244 |
| SNPdbe | rs680244 |
| MSV3d | rs680244 |
| Gene | CHRNA5 |
| Chromosome | 15 |
| Orientation | minus |
| GMAF | 0.3274 |
| Position | 78871288 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude |
| Make rs680244(A;A) |
| Make rs680244(A;G) |
| Make rs680244(G;G) |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
[PMID 16314871] Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes.
[PMID 17373692] No evidence for association between 19 cholinergic genes and bipolar disorder.
[PMID 18163978] The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.
[PMID 18519524] Variants in nicotinic receptors and risk for nicotine dependence.
[PMID 19064933] Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.
[PMID 19436041] Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.
[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
[PMID 19706762] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
[PMID 20700436] Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
[PMID 20808433] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.
[PMID 21268243] Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.
| GET Evidence | |
|---|---|
| rs680244 | |
| aa_change | |
| aa_change_short | |
| impact | pharmacogenetic |
| qualified_impact | Insufficiently evaluated pharmacogenetic |
| overall_frequency | 0.671875 |
| summary | |
