Rs680244

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Orientationminus
Make rs680244(A;A)
Make rs680244(A;G)
Make rs680244(G;G)
ReferenceGRCh38 38.1/141
Chromosome15
Position78578946
GeneCHRNA5
is asnp
is mentioned by
dbSNPrs680244
Exacrs680244
PheGenIrs680244
nextbiors680244
hapmaprs680244
1000 genomesrs680244
hgdprs680244
ensemblrs680244
gopubmedrs680244
geneviewrs680244
scholarrs680244
googlers680244
pharmgkbrs680244
gwascentralrs680244
openSNPrs680244
23andMers680244
23andMe allrs680244
SNP Nexus

SNPshotrs680244
SNPdbers680244
MSV3drs680244
GMAF0.3274
? (A;A) (A;G) (G;G) 28


[PMID 16314871] Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes.


[PMID 17373692OA-icon.png] No evidence for association between 19 cholinergic genes and bipolar disorder.


[PMID 18163978OA-icon.png] The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.


[PMID 18519524OA-icon.png] Variants in nicotinic receptors and risk for nicotine dependence.


[PMID 19064933OA-icon.png] Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.


[PMID 19436041OA-icon.png] Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.


[PMID 19443489OA-icon.png] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.


[PMID 19706762OA-icon.png] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.


[PMID 20700436OA-icon.png] Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.


[PMID 20808433OA-icon.png] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.


[PMID 21268243] Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.


GET Evidence
rs680244
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.671875
summary