From SNPedia
rs6749447 is a SNP in the serine threonine kinase 39 STK39 gene.
A study of ~1,000 Amish originally identified rs6749447 and another SNP also in the STK39 gene, rs3754777, as being significantly associated with hypertension. This association was then found to also hold in patient data analyzed from the Framingham Heart Study and the Diabetes Genetics Initiative. On average, each minor allele, in this case rs6749447(G), is associated with 2.0 mmHg higher systolic blood pressure and a 1.0 mm Hg higher diastolic pressure.10.1073/pnas.0808358106
| ? | (G;G) (G;T) (T;T) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 19114657]
|
| Trait
| Blood pressure
|
| Title
| Whole-genome association study identifies STK39 as a hypertension susceptibility gene
|
| Risk Allele
| G
|
| P-val
| 2E-7
|
| Odds Ratio
| 1.90 [1.2-2.6] mm Hg increase in DBP
|
| PharmGKB | PA164740097 |
| Name | |
| Annotation | GWAS results: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. (Initial Sample Size: 542 individuals; Replication Sample Size: 6,583 individuals); (Region: 2q24.3; Reported Gene(s): STK39; Risk Allele: rs6749447-G); (p-value= 0.0000002).This variant is associated with Blood pressure. |
| Gene | STK39 |
| Featue | |
| Evidence | PubMed ID:19114657; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | |
| Curation Level | Non-Curated |
