Rs660895

This SNP, along with SNPs rs6910071 and rs3817964, is a tag SNP for the HLA-DRB1*0401 allele.

The HLA-DRB1*0401 allele has been associated with higher risk for rheumatoid arthritis, and in particular, rheumatoid vasculitis. The association is seen particularly for individuals carrying two copies of, i.e. homozygous for, the allele. The reported odds ratio for rs660895(G;G) homozygotes is 6.2 (CI: 1.01 - 37.9). [PMID 15529352]

The risk for rheumatoid arthritis may be higher for individuals carrying one copy (one "dose") of the HLA-DRB1*0401 allele, if they also carry a different HLA-DRB1 risk allele. In particular, *0401/*0404 individuals are reported to have an odds ratio for rheumatoid vasculitis of 4.1 (CI: 1.1 - 16.2), and *0401/*0101 individuals have an odds ratio of 4.0 (CI: 1.4 - 11.6). [PMID 15529352]

• (A;A) is 0 dose of HLA-DRB1*0401
• (A;G) is 1 dose of HLA-DRB1*0401

GWAS snp
PMID	[PMID 17804836]
Trait	Rheumatoid arthritis
Title	TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
Risk Allele
P-val	1E-108
Odds Ratio	3.62 [NR]

GWAS snp
PMID	[PMID 22197929]
Trait
Title	A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
Risk Allele	G
P-val	4E-20
Odds Ratio	1.3400 None

[PMID 22355377] Caucasian and asian specific rheumatoid arthritis risk Loci reveal limited replication and apparent allelic heterogeneity in north indians