Rs6604026

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Gene

Chromosome

1

plus

Position

93303603

Reference

GRCh37 37.1/131

2

?	(C;C) (C;T) (T;T)	28

rs6604026 has been reported in a large study to be associated with multiple sclerosis.

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with this allele is 1.15 (CI 1.08-1.22). [PMID 17660530]

GWAS snp
PMID	[PMID 19525955]
Trait	Multiple sclerosis
Title	Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Risk Allele	G
P-val	0.000003
Odds Ratio	1.17 [NR]

[PMID 18650830] Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians

PharmGKB	PA162356685
Name
Annotation	GWAS Results: Risk alleles for multiple sclerosis identified by a genomewide study (Initial Sample Size: 931 trios, 2,431 controls; Replication Sample Size: 609 trios, 2,322 cases, 2,987 controls; Risk Allele: rs6604026-C).
Gene	RPL5, SNORD21, FAM69A, SNORA66
Featue
Evidence	PubMed ID:17660530; Web Resource:http://www.genome.gov/gwastudies/
Drugs
Diseases	Multiple Sclerosis
Curation Level	Non-Curated

PharmGKB	PA162356162
Name
Annotation	In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
Gene	RPL5, SNORD21, FAM69A, SNORA66
Featue
Evidence	PubMed ID:17660530
Drugs
Diseases	Multiple Sclerosis
Curation Level	Curated