Rs6604026

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs6604026
PheGenI	rs6604026
nextbio	rs6604026
hapmap	rs6604026
1000 genomes	rs6604026
hgdp	rs6604026
ensembl	rs6604026
gopubmed	rs6604026
geneview	rs6604026
scholar	rs6604026
google	rs6604026
pharmgkb	rs6604026
gwascentral	rs6604026
openSNP	rs6604026
23andMe	rs6604026
23andMe all	rs6604026
SNP Nexus
SNPshot	rs6604026
SNPdbe	rs6604026
MSV3d	rs6604026

Gene	FAM69A, RPL5

Chromosome

1

Orientation

plus

GMAF

0.2161

Position

93303603

Reference

GRCh37.p5 37.3/137

Max Magnitude

2

Geno	Mag	Summary
(C;C)	2	>1.15x risk
(C;T)		1.15x risk
(T;T)	0	common

?	(C;C) (C;T) (T;T)	28

rs6604026 has been reported in a large study to be associated with multiple sclerosis.

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with this allele is 1.15 (CI 1.08-1.22). [PMID 17660530]

GWAS
SNP	rs6604026
PubMedID	[PMID 17660530]
Condition	Multiple sclerosis
Gene	RPL5
Risk Allele	C
pValue	8.00E-006
OR	1.15
95% CI	1.08-1.22

GWAS snp
PMID	[PMID 19525955]
Trait	Multiple sclerosis
Title	Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Risk Allele	G
P-val	0.000003
Odds Ratio	1.17 [NR]

[PMID 18650830] Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians

[PMID 20368992] Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.

[PMID 20405052] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

GET Evidence
rs6604026
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.242188
summary