Rs6604026

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Orientationplus
is asnp
is mentioned by
dbSNPrs6604026
PheGenIrs6604026
hapmaprs6604026
1000 genomesrs6604026
hgdprs6604026
ensemblrs6604026
gopubmedrs6604026
geneviewrs6604026
scholarrs6604026
googlers6604026
pharmgkbrs6604026
gwascentralrs6604026
openSNPrs6604026
23andMers6604026
23andMe allrs6604026
SNP Nexus

SNPshotrs6604026
SNPdbers6604026
MSV3drs6604026
GeneFAM69A, RPL5
Chromosome1
Orientationplus
GMAF0.2167
Position92838046
ReferenceGRCh38 38.1/141
Max Magnitude2
Geno Mag Summary
(C;C) 2 >1.15x risk
(C;T) 1.5 1.15x risk
(T;T) 0 common
? (C;C) (C;T) (T;T) 28
rs6604026 has been reported in a large study to be associated with multiple sclerosis.

The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with this allele is 1.15 (CI 1.08-1.22). [PMID 17660530]

GWAS
SNP rs6604026
PubMedID [PMID 17660530]
Condition Multiple sclerosis
Gene RPL5
Risk Allele C
pValue 8.00E-006
OR 1.15
95% CI 1.08-1.22


GWAS snp
PMID [PMID 19525955]
Trait Multiple sclerosis
Title Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
Risk Allele G
P-val 0.000003
Odds Ratio 1.17 [NR]

[PMID 18650830] Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians




[PMID 20368992OA-icon.png] Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.


[PMID 20405052OA-icon.png] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.


GET Evidence
rs6604026
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.242188
summary