Rs6602024

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Orientationplus
Geno Mag Summary
(A;A) 1-3 body mass index units heavier on average
(A;G)  ?
(G;G) 0 normal
ReferenceGRCh37 37.1/131
Chromosome10
Position3155237
GenePFKP
is asnp
is mentioned by
dbSNPrs6602024
Exacrs6602024
PheGenIrs6602024
nextbiors6602024
hapmaprs6602024
1000 genomesrs6602024
hgdprs6602024
ensemblrs6602024
gopubmedrs6602024
geneviewrs6602024
scholarrs6602024
googlers6602024
pharmgkbrs6602024
gwascentralrs6602024
openSNPrs6602024
23andMers6602024
23andMe allrs6602024
SNP Nexus

SNPshotrs6602024
SNPdbers6602024
MSV3drs6602024
GMAF0.1079
Max Magnitude0
? (A;A) (A;G) (G;G) 28
[PMID 17658951OA-icon.png]
  • Within the PFKP gene, rs6602024 showed very strong association with BMI (p = 4.9 * 10-6). Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12) were 1.8 BMI units heavier than homozygotes for the common "G" allele.
  • They did not replicate association between rs6602024 and obesity-related traits in the GenNet sample, although they found that in European Americans, Hispanic Americans and African Americans, homozygotes for the rare "A" allele where, on average, 1.0 - 3.0 BMI units heavier than homozygotes for the more common "G" allele.

Furthermore, a study of 18,000 Danish subjects also failed to find any direct role for this SNP in the development of obesity.[PMID 18682847OA-icon.png]

[PMID 18325910OA-icon.png] Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.

[PMID 20018076OA-icon.png] Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort.

[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 22993228OA-icon.png] Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.