Rs6564851

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Orientationplus
is asnp
is mentioned by
dbSNPrs6564851
PheGenIrs6564851
nextbiors6564851
hapmaprs6564851
1000 genomesrs6564851
hgdprs6564851
ensemblrs6564851
gopubmedrs6564851
geneviewrs6564851
scholarrs6564851
googlers6564851
pharmgkbrs6564851
gwascentralrs6564851
openSNPrs6564851
23andMers6564851
23andMe allrs6564851
SNP Nexus

SNPshotrs6564851
SNPdbers6564851
MSV3drs6564851
Chromosome16
Orientationplus
GMAF0.4316
Position81264597
ReferenceGRCh37 37.1/131
Max Magnitude
Geno Mag Summary
(G;G) higher beta-carotene levels
(G;T) higher beta-carotene levels
(T;T) normal
? (G;G) (G;T) (T;T) 28
[PMID 19185284OA-icon.png] rs6564851(G) associated with higher beta-carotene (p = 1.6 x 10(-24)) and alpha-carotene (p = 0.0001) levels and lower lycopene (0.003), zeaxanthin (p = 1.3 x 10(-5)), and lutein (p = 7.3 x 10(-15)) levels, with effect sizes ranging from 0.10-0.28 SDs per allele.

Note that low plasma levels of carotenoids and tocopherols are associated with increased risk of chronic disease and disability, yet dietary intake of these lipid-soluble antioxidant vitamins is only poorly correlated with plasma levels, leading to the hypothesis that it isn't what you eat, it's your SNPs that regulate your carotenoid levels.[PMID 19185284OA-icon.png]

This is one of the SNPs reported by NutraHacker.

OMIM115300
DescHYPERCAROTENEMIA AND VITAMIN A DEFICIENCY, AUTOSOMAL DOMINANT
Variant
Relatedalso
[PMID 19662379OA-icon.png] Circulating beta-carotene levels and type 2 diabetes-cause or effect?


[PMID 20616999OA-icon.png] Usefulness of Mendelian randomization in observational epidemiology.


[PMID 22113863] Single nucleotide polymorphisms upstream from the beta-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers.


GET Evidence
rs6564851
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.453125
summary



[PMID 23468552] Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.