Rs6539137

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is asnp
is mentioned by
dbSNPrs6539137
hapmaprs6539137
hgdprs6539137
ensemblrs6539137
gopubmedrs6539137
scholarrs6539137
googlers6539137
pharmgkbrs6539137
hgvbaseg2prs6539137
medrefsnprs6539137
23andMers6539137
SNP Nexus

GeneTXNRD1
Chromosome12
Orientationplus
Position103231309
GenotypeEffect
rs6539137(A;A)increased risk for and earlier onset in males of familial ALS
rs6539137(A;T)
rs6539137(T;T)normal


Genotypes Magnitude Summary
Rs6539137(A;A) increased risk for and earlier onset in males of familial ALS
Rs6539137(A;T)
Rs6539137(T;T) normal
[PMID 18996185] rs6539137 is one of several TXNRD1 SNPs significantly associated with familial amyotrophic lateral sclerosis (FALS) but not sporadic amyotrophic lateral sclerosis (ALS). The risk allele, rs6539137(A), is also associated with an earlier age of onset by 8 years, and the shift was more significant in males (in fact, insignificant in females).
? (A;A) (A;T) (T;T)
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