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|On GW 5.0|
|Odds Ratio Het|
|Odds Ratio Hom|
|Odds Ratio All||1.43|
|Disease||Substance dependence, Alcohol (SD-A)|
rs6495306 increases susceptibility to Substance dependence, Alcohol 1.43 times for carriers of the G allele [PMID 18414406]
[PMID 19064933] Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.
[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
[PMID 19706762] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.