Rs6494696

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is asnp
is mentioned by
dbSNPrs6494696
hapmaprs6494696
hgdprs6494696
ensemblrs6494696
gopubmedrs6494696
scholarrs6494696
googlers6494696
pharmgkbrs6494696
hgvbaseg2prs6494696
medrefsnprs6494696
23andMers6494696
SNP Nexus

Chromosome15
Orientationplus
Position65890260
GenotypeEffect
rs6494696(C;C)<0.71x risk for restless legs
rs6494696(C;G)0.71x risk for restless legs
rs6494696(G;G)common


Genotypes Magnitude Summary
Rs6494696(C;C) <0.71x risk for restless legs
Rs6494696(C;G) 0.71x risk for restless legs
Rs6494696(G;G) 00 common
rs6494696, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (C) minor allele. [PMID 17637780]

The association between this SNP and RLS has been replicated in three European populations.[PMID 19279021]

? (C;C) (C;G) (G;G)
Related to RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 1 according to omim 102300. See also


PharmGKBPA162355634
Name
AnnotationIn replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs6494696 was significantly associated with Restless Legs Syndrome.
Gene-
Featue
EvidencePubMed ID:17637780
Drugs
DiseasesRestless Legs Syndrome
Curation LevelCurated
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