Rs603965

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Merged intors9344
is asnp
is mentioned by
dbSNPrs603965
nextbiors603965
hapmaprs603965
1000 genomesrs603965
hgdprs603965
ensemblrs603965
gopubmedrs603965
scholarrs603965
googlers603965
pharmgkbrs603965
gwascentralrs603965
openSNPrs603965
23andMers603965
23andMe allrs603965
SNP Nexus

SNPshotrs603965
SNPdbers603965
MSV3drs603965
StatusMerged into rs9344
GeneCCND1
Chromosome11
Orientationplus
Position69462910
ReferenceGRCh37 37.1/131
Max Magnitude0
Geno Mag Summary
(A;A) 0 normal
(A;G)  ?
(G;G) increased breast cancer risk
? (A;A) (A;G) (G;G) 28
rs603965 is a SNP in the cyclin D1 CCND1 gene. It is also known as Pro241Pro. The associated genotypes are characterized in terms of their enzymatic activity as High for (A;A), Medium (A;G), and Low (G;G).

In a study of 2 populations of breast cancer patients (2,000+ patients), increased risk was associated with rs603965(A;A) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.[PMID 18194538]

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