Rs578776
| Orientation | minus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs578776 |
| PheGenI | rs578776 |
| nextbio | rs578776 |
| hapmap | rs578776 |
| 1000 genomes | rs578776 |
| hgdp | rs578776 |
| ensembl | rs578776 |
| gopubmed | rs578776 |
| geneview | rs578776 |
| scholar | rs578776 |
| rs578776 | |
| pharmgkb | rs578776 |
| gwascentral | rs578776 |
| openSNP | rs578776 |
| 23andMe | rs578776 |
| 23andMe all | rs578776 |
| SNP Nexus | |
| SNPshot | rs578776 |
| SNPdbe | rs578776 |
| MSV3d | rs578776 |
| Gene | CHRNA3 |
| Chromosome | 15 |
| Orientation | minus |
| GMAF | 0.4565 |
| Position | 78888400 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude |
| Make rs578776(C;C) |
| Make rs578776(C;T) |
| Make rs578776(T;T) |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
[PMID 19706762] The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans
[PMID 20587604] Fine Mapping of Chromosome 15q25.1 Lung Cancer Susceptibility in African Americans
[PMID 20700436] Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
[PMID 20840187] Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence
[PMID 22046326] 'Smoking Genes': A Genetic Association Study
[PMID 17135278] Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.
[PMID 18519524] Variants in nicotinic receptors and risk for nicotine dependence.
[PMID 18565990] Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
[PMID 18571741] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
[PMID 18780872] Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
[PMID 18783506] Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
[PMID 19029397] Nicotinic receptor gene variants influence susceptibility to heavy smoking.
[PMID 19184766] A testable prognostic model of nicotine dependence.
[PMID 19247474] Genome-wide and candidate gene association study of cigarette smoking behaviors.
[PMID 19436041] Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.
[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
[PMID 20485328] Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.
[PMID 20808433] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.
[PMID 20886544] Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.
[PMID 21385908] Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.
[PMID 21810735] Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada.
[PMID 21862624] Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
[PMID 22241830] Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.
| GET Evidence | |
|---|---|
| rs578776 | |
| aa_change | |
| aa_change_short | |
| impact | pharmacogenetic |
| qualified_impact | Insufficiently evaluated pharmacogenetic |
| overall_frequency | 0.4375 |
| summary | |
[PMID 23397474] Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population
