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1000 genomesrs578776
23andMe allrs578776
SNP Nexus

ReferenceGRCh38 38.1/141
Max Magnitude
Make rs578776(C;C)
Make rs578776(C;T)
Make rs578776(T;T)
? (C;C) (C;T) (T;T) 28
[PMID 19259974OA-icon.png] identifies a region associated with nicotine dependence in this particular study (1,050 dependents, 879 non-dependent controls, all of European descent), noted as distinct from the loci which rs16969968 defines

[PMID 19706762OA-icon.png] The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

[PMID 20587604OA-icon.png] Fine Mapping of Chromosome 15q25.1 Lung Cancer Susceptibility in African Americans

[PMID 20700436OA-icon.png] Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

[PMID 20840187OA-icon.png] Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence

[PMID 22046326OA-icon.png] 'Smoking Genes': A Genetic Association Study

[PMID 17135278OA-icon.png] Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

[PMID 18519524OA-icon.png] Variants in nicotinic receptors and risk for nicotine dependence.

[PMID 18565990OA-icon.png] Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.

[PMID 18571741OA-icon.png] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.

[PMID 18780872OA-icon.png] Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.

[PMID 18783506OA-icon.png] Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.

[PMID 19029397OA-icon.png] Nicotinic receptor gene variants influence susceptibility to heavy smoking.

[PMID 19184766OA-icon.png] A testable prognostic model of nicotine dependence.

[PMID 19247474OA-icon.png] Genome-wide and candidate gene association study of cigarette smoking behaviors.

[PMID 19436041OA-icon.png] Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.

[PMID 19443489OA-icon.png] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

[PMID 20485328OA-icon.png] Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.

[PMID 20808433OA-icon.png] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.

[PMID 20886544] Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

[PMID 21385908OA-icon.png] Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.

[PMID 21810735] Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada.

[PMID 21862624] Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.

[PMID 22241830OA-icon.png] Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.

GET Evidence
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.4375

[PMID 23397474OA-icon.png] Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population

[PMID 22884254] Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction.

[PMID 23689675] Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.

[PMID 23692359] CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

[PMID 25139936] Association of Cancer Susceptibility Variants with Risk of Multiple Primary Cancers: the Population Architecture using Genomics and Epidemiology Study