Rs578776

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Orientationminus
is asnp
is mentioned by
dbSNPrs578776
PheGenIrs578776
nextbiors578776
hapmaprs578776
1000 genomesrs578776
hgdprs578776
ensemblrs578776
gopubmedrs578776
geneviewrs578776
scholarrs578776
googlers578776
pharmgkbrs578776
gwascentralrs578776
openSNPrs578776
23andMers578776
23andMe allrs578776
SNP Nexus

SNPshotrs578776
SNPdbers578776
MSV3drs578776
GeneCHRNA3
Chromosome15
Orientationminus
GMAF0.4564
Position78888400
ReferenceGRCh37 37.1/131
Max Magnitude
Make rs578776(C;C)
Make rs578776(C;T)
Make rs578776(T;T)
? (C;C) (C;T) (T;T) 28
[PMID 19259974OA-icon.png] identifies a region associated with nicotine dependence in this particular study (1,050 dependents, 879 non-dependent controls, all of European descent), noted as distinct from the loci which rs16969968 defines


[PMID 19706762OA-icon.png] The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans



[PMID 20587604OA-icon.png] Fine Mapping of Chromosome 15q25.1 Lung Cancer Susceptibility in African Americans

[PMID 20700436OA-icon.png] Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

[PMID 20840187OA-icon.png] Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence


[PMID 22046326OA-icon.png] 'Smoking Genes': A Genetic Association Study

[PMID 17135278OA-icon.png] Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

[PMID 18519524OA-icon.png] Variants in nicotinic receptors and risk for nicotine dependence.

[PMID 18565990OA-icon.png] Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.

[PMID 18571741OA-icon.png] Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.

[PMID 18780872OA-icon.png] Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.

[PMID 18783506OA-icon.png] Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.

[PMID 19029397OA-icon.png] Nicotinic receptor gene variants influence susceptibility to heavy smoking.

[PMID 19184766OA-icon.png] A testable prognostic model of nicotine dependence.

[PMID 19247474OA-icon.png] Genome-wide and candidate gene association study of cigarette smoking behaviors.

[PMID 19436041OA-icon.png] Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.

[PMID 19443489OA-icon.png] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

[PMID 20485328OA-icon.png] Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.

[PMID 20808433OA-icon.png] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.

[PMID 20886544] Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

[PMID 21385908OA-icon.png] Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.

[PMID 21810735] Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada.

[PMID 21862624] Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.

[PMID 22241830OA-icon.png] Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.


GET Evidence
rs578776
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.4375
summary



[PMID 23397474OA-icon.png] Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population


[PMID 22884254] Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction.


[PMID 23689675] Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.


[PMID 23692359] CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.