Rs5751876
| is a | snp |
| is | mentioned by |
| dbSNP | rs5751876 |
| nextbio | rs5751876 |
| hapmap | rs5751876 |
| 1000 genomes | rs5751876 |
| hgdp | rs5751876 |
| ensembl | rs5751876 |
| gopubmed | rs5751876 |
| scholar | rs5751876 |
| rs5751876 | |
| pharmgkb | rs5751876 |
| gwascentral | rs5751876 |
| openSNP | rs5751876 |
| 23andMe | rs5751876 |
| 23andMe all | rs5751876 |
| SNP Nexus | |
| SNPshot | rs5751876 |
| SNPdbe | rs5751876 |
| MSV3d | rs5751876 |
| Gene | ADORA2A |
| Chromosome | 22 |
| Orientation | plus |
| Position | 24837301 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 2.1 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | None |
| (C;T) | 0 | None |
| (T;T) | 2.1 | significantly higher anxiety levels after moderate caffeine consumption |
T/T carriers displaying significantly increased subjective levels of anxiety after consumption. [PMID 12825092] [PMID 18305461]
However a PharmGKB variant annotation suggests it is (C;C) genotypes who are more sensitive to caffeine.
rs5751876 is not associated with how much coffee one drinks, though, nor with risk for Parkinson's disease, based on a study of 1,200 subjects.[PMID 18759349]
[PMID 19902562] Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians
[PMID 20334879] Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality
"rs2298383 shows functional potential based on in silico analyses and might therefore represent the true underlying causal variant"
[PMID 21658325] Adenosine A2A receptor polymorphisms in Korean patients with systemic sclerosis
[PMID 22012471] ADORA2A Gene Variation, Caffeine, and Emotional Processing: A Multi-level Interaction on Startle Reflex
