Rs5751876

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is asnp
is mentioned by
dbSNPrs5751876
hapmaprs5751876
hgdprs5751876
ensemblrs5751876
gopubmedrs5751876
scholarrs5751876
googlers5751876
pharmgkbrs5751876
hgvbaseg2prs5751876
medrefsnprs5751876
23andMers5751876
SNP Nexus

GeneADORA2A
Chromosome22
Orientationplus
Position24837301
ReferenceGRCh37 37.1/131
GenotypeEffect
rs5751876(C;C)None
rs5751876(C;T)None
rs5751876(T;T)significantly higher anxiety levels after moderate caffeine consumption


Genotypes Magnitude Summary
Rs5751876(C;C) None
Rs5751876(C;T) None
Rs5751876(T;T) 2.12.1 significantly higher anxiety levels after moderate caffeine consumption
Variation at this SNP, rs5751876, also referred to as 1976C>T or 1976T>C, appears to influence how an individual responds to moderate levels (150mg) of caffeine, with T/T carriers displaying significantly increased subjective levels of anxiety after consumption. [PMID 12825092] [PMID 18305461]

rs5751876 is not associated with how much coffee one drinks, though, nor with risk for Parkinson's disease, based on a study of 1,200 subjects.[PMID 18759349]


[PMID 19902562] Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians

[PMID 20334879] Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality

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