Rs53576
| influences social behavior and personality |
| Orientation | plus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs53576 |
| PheGenI | rs53576 |
| nextbio | rs53576 |
| hapmap | rs53576 |
| 1000 genomes | rs53576 |
| hgdp | rs53576 |
| ensembl | rs53576 |
| gopubmed | rs53576 |
| geneview | rs53576 |
| scholar | rs53576 |
| rs53576 | |
| pharmgkb | rs53576 |
| gwascentral | rs53576 |
| openSNP | rs53576 |
| 23andMe | rs53576 |
| 23andMe all | rs53576 |
| SNP Nexus | |
| SNPshot | rs53576 |
| SNPdbe | rs53576 |
| MSV3d | rs53576 |
| Gene | OXTR |
| Chromosome | 3 |
| Orientation | plus |
| GMAF | 0.4116 |
| Position | 8804371 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 2.8 |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2.8 | lack of empathy? |
| (G;G) | 2.5 | optimistic and empathetic |
| Make rs53576(A;G) |
rs53576 is a silent G to A change in the oxytocin receptor (OXTR) gene.
The blog Not Exactly Rocket Science discusses that Americans with (G;G) tend to be more sensitive parents, more empathetic and less lonely than those with an ‘A’. In a Korean population people with (G;G) were less likely to seek support from their peers.
[PMID 20724662] Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking.
[PMID 19934046] Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. With a blog summary, shows that people with the (G;G) genotype were better able to discern the emotional state of others than those who carried the A-allele.
[PMID 19376182] Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects.
[PMID 19015103] Oxytocin receptor and serotonin transporter (5-HTT) genes associated with observed parenting.
[PMID 22069391] Oxytocin receptor gene associated with the efficiency of social auditory processing
[PMID 22084107] Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition
Followup:
[PMID 22499788] Misuse of hierarchical linear models overstates the significance of a reported association between OXTR and prosociality.
[PMID 22123970] Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
23andMe blog discusses the snp.
blogs.scientificamerican discusses the snp.
[PMID 22357335] The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy
[PMID 22763666] The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype
[PMID 15992526] Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.
[PMID 17383819] Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.
[PMID 18687882] Genetic correlates of adult attachment style.
[PMID 19515497] Oxytocin receptor polymorphisms and adult attachment style in patients with depression.
[PMID 20347913] Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD.
[PMID 20585395] No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences.
[PMID 20647384] A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function.
[PMID 21896752] Oxytocin receptor gene (OXTR) is related to psychological resources.
[PMID 22372486] The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression.
[PMID 22487732] Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.
[PMID 22563705] Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes.
[PMID 22580735] Breastfeeding and its relation to maternal sensitivity and infant attachment.
[PMID 23089921] Common oxytocin receptor gene polymorphisms and the risk for preterm birth
[PMID 23284802] Association between Oxytocin Receptor Gene Polymorphisms and Self-Rated 'Empathic Concern' in Schizophrenia
[PMID 23470776] Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress
