Rs523349

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is asnp
is mentioned by
dbSNPrs523349
hapmaprs523349
hgdprs523349
ensemblrs523349
gopubmedrs523349
scholarrs523349
googlers523349
pharmgkbrs523349
hgvbaseg2prs523349
medrefsnprs523349
23andMers523349
SNP Nexus

GeneSRD5A2
Chromosome2
Orientationplus
Position31659209
GenotypeEffect
rs523349(C;C)normal
rs523349(C;G)increased ovarian cancer risk
rs523349(G;G)increased ovarian cancer risk


Genotypes Magnitude Summary
Rs523349(C;C) 00 normal
Rs523349(C;G) increased ovarian cancer risk
Rs523349(G;G) increased ovarian cancer risk

rs523349 is a SNP in the steroid-5-alpha-reductase SRD5A2 gene; it is also known as V89L.

In a study of a total of 1,466 Caucasian cases of ovarian cancer, the rs523349(G) allele showed a significant trend of increasing risk of ovarian cancer per rare allele (p = 0.00002).[PMID 18086758]

Neighborrs9282858
Distance120
? (C;C) (C;G) (G;G)

[PMID 18431743] showed no association with ovarian cancer risk 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin ovarian cancer


[PMID 19926884] Analysis of Polymorphisms in the SRD5A2 Gene and Semen Parameters in Estonian Men


[PMID 19914946] Steroid 5-{alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review

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