From SNPedia
| ? | (C;C) (C;G) (G;G) | 28 |
|---|
 |
, also known as -697G/C, is a SNP in the 5-hydroxytryptamine (serotonin) receptor 2C
HTR2C gene.
A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (C) allele of this SNP; fewer patients (of 28) with a rs518147(C) allele had a body mass index increase of >=10% (p=0.0006), whereas (G;G) homozygotes did. This effect may also involve nearby SNP rs3813929.[PMID 19434072]
[PMID 19416518] Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples
| PharmGKB | PA164924605 |
| Name | HTR2C: -697G/C |
| Annotation | This variant is associated with Olanzapine-induced weight gain. The -697C allele confers protective effect towards Olanzapine-induced weight gain in a study consisting of 107 patients with schizophrenia. |
| Gene | HTR2C |
| Featue | |
| Evidence | PubMed ID:19622037 |
| Drugs | olanzapine |
| Diseases | Schizophrenia, Weight gain |
| Curation Level | Curated |
