rs509749

plus

Geno	Mag	Summary
(A;A)	0	common; slight increase in SLE risk
(A;G)	0	common; slight increase in SLE risk
(C;T)	0
(G;G)		rarer; slight decrease in SLE risk

Reference

GRCh38 38.1/141

Chromosome

1

Position

160823770

Gene

LY9

is a	snp
is	mentioned by
dbSNP	rs509749
dbSNP (classic)	rs509749
ClinGen	rs509749
ebi	rs509749
HLI	rs509749
Exac	rs509749
Gnomad	rs509749
Varsome	rs509749
LitVar	rs509749
Map	rs509749
PheGenI	rs509749
Biobank	rs509749
1000 genomes	rs509749
hgdp	rs509749
ensembl	rs509749
geneview	rs509749
scholar	rs509749
google	rs509749
pharmgkb	rs509749
gwascentral	rs509749
openSNP	rs509749
23andMe	rs509749
SNPshot	rs509749
SNPdbe	rs509749
MSV3d	rs509749
GWAS Ctlg	rs509749

GMAF

0.3747

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs509749 is a SNP in exon 8 of the LY9 gene; this SNP is also known as Met602Val. The (A) allele encodes the Met; the (G) allele encodes the Val.

The rarer (G) allele is undertransmitted in a family-based association study of systemic lupus erythematosus, leading to the conclusion that the (A) allele increases risk for SLE by increasing cytokine production and thereby enhancing the immune response.[PMID 18216865]

[PMID 19714582] Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors

[PMID 19442287 ] Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.

[PMID 19838195 ] A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.