From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
1.12x risk on diuretic; if hypertensive, better outcome when treated with calcium channel blocker than with diuretic
|
| (A;G)
|
0
|
normal risk
|
| (G;G)
|
|
0.87x risk on diuretic; if hypertensive, better outcome when treated with diuretic than with calcium channel blocker
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
, also known as T2238C, is a SNP in the atrial natriuretic precursor A
NPPA gene.
A large study has been conducted in which 42,418 hypertensive participants 55 or older were followed for several years while on one of four medications: a diuretic, a calcium antagonist, an angiotensin-converting enzyme inhibitor, or an alpha-blocker. The primary endpoint was either fatal heart disease or a heart attack.[PMID 18212314]
The blood pressure after six months of rs5065(G;G) patients (note: genotype is in dbSNP orientation, not as published) was lower if the patients were treated with diuretics compared to other medications, with smaller variation seen for (A;A) genotypes. The authors noted that none of the findings retained statistical significance after correction for multiple comparisons, but since the trend held in five of seven outcomes, they felt the results were nonetheless worth reporting.
In summary, rs5065(G) allele carriers were better off (i.e. experienced more favorable cardiovascular disease outcomes) if treated with the diuretic (in this case, chlorthalidone), whereas rs5065(A;A) carriers were better off if treated with the calcium channel blocker (in this case, amlodipine).
| PharmGKB | PA165111692 |
| Name | |
| Annotation | The minor allele of this SNP(G on the + strand) was associated with decreased asthma susceptibility. This PMID is a correction to the original (PMID: 19264973); details of the study are in that article. |
| Gene | NPPA, CLCN6 |
| Featue | Exon/NonSyn, NA |
| Evidence | PubMed ID:20026756 |
| Drugs | |
| Diseases | Asthma |
| Curation Level | Curated |
[PMID 20543198] Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation
