Rs4988235
| Orientation | minus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4988235 |
| PheGenI | rs4988235 |
| nextbio | rs4988235 |
| hapmap | rs4988235 |
| 1000 genomes | rs4988235 |
| hgdp | rs4988235 |
| ensembl | rs4988235 |
| gopubmed | rs4988235 |
| geneview | rs4988235 |
| scholar | rs4988235 |
| rs4988235 | |
| pharmgkb | rs4988235 |
| gwascentral | rs4988235 |
| openSNP | rs4988235 |
| 23andMe | rs4988235 |
| 23andMe all | rs4988235 |
| SNP Nexus | |
| SNPshot | rs4988235 |
| SNPdbe | rs4988235 |
| MSV3d | rs4988235 |
| Gene | MCM6 |
| Chromosome | 2 |
| Orientation | minus |
| GMAF | 0.2335 |
| Position | 136608646 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 1.1 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 1.1 | possibly lactose intolerant |
| (C;T) | can digest milk | |
| (T;T) | can digest milk |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
In these populations, the rs4988235(T) allele is both the more common allele and the one associated with lactase persistence; individuals who are rs4988235(C;C) are likely to be lactose intolerant.
In populations of sub-Saharan Africans, though, the rs4988235(T) allele is so rare that it's unlikely to be predictive of lactase persistence, and other SNPs are predictive instead. [PMID 15106124, PMID 17159977]
- See also OMIM 601806.0001
[PMID 20225268] The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake
[PMID 20447925] Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization
[PMID 22572735] Lactase persistence may have an independent origin in Tibetan populations from Tibet, China
[PMID 17436249] Measuring European population stratification with microarray genotype data.
[PMID 18194137] Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study.
[PMID 18462498] Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.
[PMID 18602983] Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1.
[PMID 18605960] Genetic testing for adult-type hypolactasia in Italian families.
[PMID 18797476] Lactase persistence-related genetic variant: population substructure and health outcomes.
[PMID 18974842] Gender differences in genetic risk profiles for cardiovascular disease.
[PMID 19138442] Genetic lactase non-persistence, consumption of milk products and intakes of milk nutrients in Finns from childhood to young adulthood.
[PMID 19265028] Geographical structure and differential natural selection among North European populations.
[PMID 19326473] Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
[PMID 19687126] A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.
[PMID 19943975] Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms.
[PMID 20015952] European lactase persistence genotype shows evidence of association with increase in body mass index.
[PMID 20031626] Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.
[PMID 20109229] Haplotype allelic classes for detecting ongoing positive selection.
[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.
[PMID 21152447] Adult-type hypolactasia and lactose malabsorption in Poland.
[PMID 21193851] Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population.
[PMID 21235777] Lactase persistence genotypes and malaria susceptibility in Fulani of Mali.
[PMID 22965418] Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition
[PMID 23252911] The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children.
