|(A;G)||1.1||Some studies - but not others - report a slightly increased risk for myocardial infarction|
|(G;G)||1.5||Most studies find a somewhat elevated (~1.5x) risk for myocardial infarction|
|On GW 5.0||1|
|Odds Ratio Het||1.30|
|Odds Ratio Hom||1.54|
|Odds Ratio All||1.23|
|Disease||Coronary artery disease (CAD)|
rs4977574 increases susceptibility to Coronary artery disease 1.30 times for heterozygotes (A;G) and 1.54 times for homozygotes (G;G) [PMID 17478681]
[PMID 24270849] rs4977574 was found to be associated with myocardial infarction based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.
|Trait||Myocardial infarction (early onset)|
|Title||Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants|
|Odds Ratio||1.29 [1.25-1.34]|
[PMID 21375403] The Relationship Between Polymorphisms on Chromosome 9p21 and Age of Onset of Coronary Heart Disease in Black and White Women
|Title||Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease|
|Odds Ratio||1.2900 [1.23-1.36]|
|Title||A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease|
|Odds Ratio||1.2000 [1.16-1.25]|
[PMID 22216278] Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease. In this study of 2,000 patients, rs4977574(G;G) homozygotes had an increased risk (odds ratio) for myocardial infarction of 1.84 (CI: 1.14−3.09, p = 0.011)
[PMID 18987759] Genetic testing for atherosclerosis risk: inevitability or pipe dream?
[PMID 19214202] Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.
[PMID 19463184] Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 20031606] The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people.
[PMID 20835900] Genetics of diabetes complications.
[PMID 21242481] Genetic risk score and risk of myocardial infarction in Hispanics.
[PMID 21347282] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
[PMID 22152955] Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23343465] Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
[PMID 23364394] A genome-wide association study of a coronary artery disease risk variant
[PMID 23561647] Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction
[PMID 23828831] The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk
[PMID 23856978] Higher Frequency of rs4977574 (the G Allele) on Chromosome 9p21.3 in Patients with Myocardial Infarction as Revealed by PCR-RFLP Analysis
[PMID 24069144] Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction
[PMID 23480785] Chromosome 9p21 genetic variation explains 13% of cardiovascular disease incidence but does not improve risk prediction.
[PMID 23631657] Are 25 SNPs from the CARDIoGRAM study associated with ischaemic stroke?
[PMID 24804228] The chromosome 9p21 variant not predicting long-term cardiovascular mortality in chinese with established coronary artery disease: an eleven-year follow-up study
[PMID 24998078] Omega-3 fatty acids and the genetic risk of early onset acute coronary syndrome
[PMID 25105296] Polymorphism of 9p21.3 locus is associated with 5-year survival in high-risk patients with myocardial infarction
|Title||A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.|
|Odds Ratio||1.22 [1.12-1.33]|