From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2.6
|
2.6x increased risk for Crohn's disease
|
| (A;G)
|
1.3
|
1.3x increased risk for Crohn's disease
|
| (G;G)
|
0
|
normal
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
is a SNP in the
IRGM gene.
A study of 507 CD patients, 475 UC patients and 576 controls from New Zealand Caucasians found that rs4958847, a SNP in the IRGM gene, was associated specifically with ileal Crohn's disease but not with other forms of inflammatory bowel disease. The reported odds ratio was 1.767, CI: 1.224-2.558, p=0.0022.[PMID 18580884]
Another study, including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs4958847(A) was associated with CD (p=2.78 x 10(-17), pooled odds ratio 1.31) and UC (p=0.014, pooled odds ratio 1.13).[PMID 19491842]
[PMID 19174780] Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
| OMIM | 612278 |
| Desc | INFLAMMATORY BOWEL DISEASE 19; IBD19 |
| Variant | |
| Related | also |
| OMIM | 608212 |
| Desc | IMMUNITY-RELATED GTPase FAMILY, M; IRGM |
| Variant | |
| Related | also |
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
[PMID 22228152] Mutations in IRGM Are Associated With More Frequent Need for Surgery in Patients With Ileocolonic Crohn's Disease
