Rs4950928
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs4950928 |
| hapmap | rs4950928 |
| hgdp | rs4950928 |
| ensembl | rs4950928 |
| gopubmed | rs4950928 |
| scholar | rs4950928 |
| rs4950928 | |
| pharmgkb | rs4950928 |
| hgvbaseg2p | rs4950928 |
| medrefsnp | rs4950928 |
| 23andMe | rs4950928 |
| SNP Nexus |
| Gene | CHI3L1 |
| Chromosome | 1 |
| Orientation | plus |
| Position | 201422504 |
| Genotype | Effect |
|---|---|
| rs4950928(C;C) | |
| rs4950928(C;G)* | ? |
| rs4950928(G;G)* | ? |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs4950928(C;C) | ||
| Rs4950928(G;C) |
[PMID 18767121] An attempt to repeat the association between rs4950928 and risk for schizophrenia in an ethnically identical population (Japanese) as well as a new population (Han Chinese) failed to show any significant association.
[PMID 19568425] In contrast to previous studies, in this study of 6514 Danish adults the rs4950928(G) allele - rather than the (C) allele - was found to be associated with asthma.
| ? | (C;C) (C;G) (G;G) |
|---|---|
|
| |
| Neighbor | rs10399805 |
| Distance | 116 |
| GWAS | |
|---|---|
| SNP | rs4950928 |
| PubMedID | [PMID 18403759] |
| Condition | YKL-40 levels |
| Gene | CHI3L1 |
| Risk Allele | G |
| pValue | 1.00E-013 |
| OR | 0.3 |
| 95% CI | NR) ng/ml decreas |
[PMID 19421404] Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
Related to ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 7; ASRT7
according to omim 611960. See also
Related to SCHIZOPHRENIA; SCZD
according to omim 181500. See also
Related to CHITINASE 3-LIKE 1; CHI3L1
according to omim 601525. See also
| PharmGKB | PA162356790 |
| Name | |
| Annotation | GWAS Results: Effect of Variation in CHI31 on Serum YKL-40 Level, Risk of Asthma, and Lung Function (Initial Sample Size: 632 individuals; Replication Sample Size: 206 children; Risk Allele: rs4950928-G). This variant is associated with YKL-40 levels. |
| Gene | CHI3L1 |
| Featue | |
| Evidence | PubMed ID:18403759; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | |
| Curation Level | Non-Curated |
[PMID 20051317] The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis
