rs4845622
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | normal | |
| (A;C) | 1.7x increased melanoma risk | |
| (C;C) | normal? |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 154438943 |
| Gene | IL6R |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4845622 |
| dbSNP (classic) | rs4845622 |
| ClinGen | rs4845622 |
| ebi | rs4845622 |
| HLI | rs4845622 |
| Exac | rs4845622 |
| Gnomad | rs4845622 |
| Varsome | rs4845622 |
| LitVar | rs4845622 |
| Map | rs4845622 |
| PheGenI | rs4845622 |
| Biobank | rs4845622 |
| 1000 genomes | rs4845622 |
| hgdp | rs4845622 |
| ensembl | rs4845622 |
| geneview | rs4845622 |
| scholar | rs4845622 |
| rs4845622 | |
| pharmgkb | rs4845622 |
| gwascentral | rs4845622 |
| openSNP | rs4845622 |
| 23andMe | rs4845622 |
| SNPshot | rs4845622 |
| SNPdbe | rs4845622 |
| MSV3d | rs4845622 |
| GWAS Ctlg | rs4845622 |
| GMAF | 0.3196 |
| Max Magnitude | 0 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, rs4845622, was 1.69 (CI: 1.03-2.75). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.[PMID 18781131
]
[PMID 18852330] Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.
