From SNPedia
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
is in close proximity to
CREB1, and adjacent to
LOC151194.
g2b2mh blog [PMID 18678793] individuals with the TT genotype at rs4675690 (C/T) showed less disgust, but not happiness, desire or fear.
[PMID 17548750] T allele associated with increased chance of suicide (OR = 2.3, 95% CI 1.3-2.9, TT homozygotes vs CC homozygotes?) during the first 30 days (p > 0.05 after the first month) of citalopram treatment, in a study of 1447 citalopram users (male only subgroup, 539 in total). Two haplotypes (see below) also showed significant association with suicidality in the male subgroup.
- rs2709376(C),rs2253206(A),rs7569963(A),rs7594560(T),rs4675690(C) - common haplotype, reduced chance of suicide in males, p = 0.004
- rs2709376(C),rs2253206(A),rs7569963(G),rs7594560(T),rs4675690(T) - increased chance of suicide in males, p = 0.009
[PMID 17300755] strongly associated with anger expression in male MDD patients
| PharmGKB | PA162263535 |
| Name | |
| Annotation | In a nested case-control study derived from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study this SNP in the CREB1 gene was associated with treatment-emergent suicidality among men with depression. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17548750 |
| Drugs | citalopram |
| Diseases | Depression |
| Curation Level | Curated |
[PMID 21807415] Early influence of the rs4675690 on the neural substrates of sadness
