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rs4665058

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.1 ~4x increased risk among Europeans for sudden cardiac death
(A;C) 2 2x increased risk among Europeans for sudden cardiac death
(C;C) 0 common in complete genomics
ReferenceGRCh38 38.1/141
Chromosome2
Position159333698
GeneBAZ2B
is asnp
is mentioned by
dbSNPrs4665058
dbSNP (classic)rs4665058
ClinGenrs4665058
ebirs4665058
HLIrs4665058
Exacrs4665058
Gnomadrs4665058
Varsomers4665058
LitVarrs4665058
Maprs4665058
PheGenIrs4665058
Biobankrs4665058
1000 genomesrs4665058
hgdprs4665058
ensemblrs4665058
geneviewrs4665058
scholarrs4665058
googlers4665058
pharmgkbrs4665058
gwascentralrs4665058
openSNPrs4665058
23andMers4665058
SNPshotrs4665058
SNPdbers4665058
MSV3drs4665058
GWAS Ctlgrs4665058
GMAF0.1111
Max Magnitude2.1
? (A;A) (A;C) (C;C) 28


rs4665058 is a SNP in the bromodomain adjacent zinc finger domain 2B BAZ2B locus on ch 2q24.2.

A GWAS meta-analysis in 1,283 cases of sudden cardiac death (SCD; presumably from myocardial infarction) and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in 3,000+ cases, associated rs4665058 with SCD risk (p = 1.8×10e?10). The per allele odds ratio for the risk allele, rs4665058(A), is 1.92 (CI: 1.57–2.34).10.1371/journal.pgen.1002158

GWAS snp
PMID [PMID 21738491OA-icon.png]
Trait
Title Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals.
Risk Allele A
P-val 2E-10
Odds Ratio 1.9200 [1.57-2.34]