|| ~4x increased risk among Europeans for sudden cardiac death
|| 2x increased risk among Europeans for sudden cardiac death
|| common in complete genomics
|?|| (A;A) (A;C) (C;C) ||28|
is a SNP in the bromodomain adjacent zinc finger domain 2B BAZ2B
locus on ch 2q24.2.
A GWAS meta-analysis in 1,283 cases of sudden cardiac death (SCD; presumably from myocardial infarction) and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in 3,000+ cases, associated rs4665058 with SCD risk (p = 1.8×10e?10). The per allele odds ratio for the risk allele, rs4665058(A), is 1.92 (CI: 1.57–2.34).10.1371/journal.pgen.1002158
|| [PMID 21738491]
|| Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals.
| Risk Allele
| Odds Ratio
|| 1.9200 [1.57-2.34]