Rs4665058

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Geno Mag Summary
(A;A) 2.1 ~4x increased risk among Europeans for sudden cardiac death
(A;C) 2 2x increased risk among Europeans for sudden cardiac death
(C;C) 0 common in complete genomics
ReferenceGRCh38 38.1/141
Chromosome2
Position159333698
GeneBAZ2B
is asnp
is mentioned by
dbSNPrs4665058
Exacrs4665058
PheGenIrs4665058
nextbiors4665058
hapmaprs4665058
1000 genomesrs4665058
hgdprs4665058
ensemblrs4665058
gopubmedrs4665058
geneviewrs4665058
scholarrs4665058
googlers4665058
pharmgkbrs4665058
gwascentralrs4665058
openSNPrs4665058
23andMers4665058
23andMe allrs4665058
SNP Nexus

SNPshotrs4665058
SNPdbers4665058
MSV3drs4665058
GMAF0.1111
? (A;A) (A;C) (C;C) 28
rs4665058 is a SNP in the bromodomain adjacent zinc finger domain 2B BAZ2B locus on ch 2q24.2.

A GWAS meta-analysis in 1,283 cases of sudden cardiac death (SCD; presumably from myocardial infarction) and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in 3,000+ cases, associated rs4665058 with SCD risk (p = 1.8×10e?10). The per allele odds ratio for the risk allele, rs4665058(A), is 1.92 (CI: 1.57–2.34).10.1371/journal.pgen.1002158

GWAS snp
PMID [PMID 21738491OA-icon.png]
Trait
Title Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals.
Risk Allele A
P-val 2E-10
Odds Ratio 1.9200 [1.57-2.34]