From SNPedia
rs4430796 is a SNP in the TCF2 gene on chromosome 17q12, associated with increased risk for prostate cancer in several studies.
In a study of over 3,600 Caucasians with prostate cancer, rs4430796 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the rs4430796(A;A) risk genotype - in dbSNP orientation, not as published - yields an odds ratio for developing prostate cancer of 1.38 (CI: 1.21-1.57, p=1.6x10e-6) and may account for 10.2% of population attributable risk.10.1056/NEJMoa075819
article linking to Prostate cancer and type-2 diabetes
[PMID 18701471] 403 non-Hispanic white families were studied, totaling 1,015 men, to reach the conclusion that the rs4430796(A) allele is associated with increased prostate cancer risk; the odds ratio was 1.40 (CI: 1.09-1.81) under an additive genetic model. Notably, rs4430796(A) was significantly associated with prostate cancer among men diagnosed at an early (<50 years) but not later age (P = 0.006 versus P = 0.118). The increased risk associated with rs4430796 and the closely linked rs7501939 is approximately doubled in individuals hereditarily predisposed to develop early-onset prostate cancer.
[PMID 19998368] rs4430796 identified as one of three HNF1B gene SNPs associated with decreased risk for prostate cancer in two large prospective studies
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 18264096]
|
| Trait
| Prostate cancer
|
| Title
| Multiple loci identified in a genome-wide association study of prostate cancer
|
| Risk Allele
| A
|
| P-val
| 1.0000000000000001E-9
|
| Odds Ratio
| 1.18 [1.04-1.32]
|
Related to PROSTATE CANCER, HEREDITARY, 11; HPC11
according to
omim 611955. See
also
Related to DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
according to
omim 125853. See
also
| GWAS snp
|
| PMID
| [PMID 19767754]
|
| Trait
| Prostate cancer
|
| Title
| Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
|
| Risk Allele
| A
|
| P-val
| 0.000008
|
| Odds Ratio
| 1.19 [1.10-1.28]
|
[PMID 19726753] Replication of prostate cancer risk loci in a Japanese case-control association study
| PharmGKB | PA162355653 |
| Name | |
| Annotation | In a fine-mapping study in the HNF1B gene at 17q12 this variant was associated with prostate cancer risk. |
| Gene | HNF1B |
| Featue | |
| Evidence | PubMed ID:18758462 |
| Drugs | |
| Diseases | Prostatic Neoplasms |
| Curation Level | Curated |
[PMID 20203524] Genetic Susceptibility to Type 2 Diabetes Is Associated with Reduced Prostate Cancer Risk
