| Associated with 73% higher IL-R and CRP levels |
| Geno
|
Mag
|
Summary
|
| (C;C)
|
1
|
No increased risk of higher IL-R and CRP levels
|
| (T;T)
|
1.2
|
Associated with 73% higher IL-R and CRP levels
|
[PMID 22029668
] A 2012 educational article explained that in autoimmune inflammatory conditions, IL-6 promotes antibody production, drives CRP levels, and has other pathological roles.
[PMID 23749187] A 2013 article titled "Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci" stated that TT homozygous at rs4129267 had sIL-6R (soluble inhibiting IL-6 receptors) concentrations 73% higher than CC homozygous (28.9 versus 16.7 ng/ml; P = 7.8 × 10−17) and CRP (C-reactive protein) concentrations were 30% higher in TT than in CC (19.2 versus 14.8 mg/l).
See further references at rs4129267
] A 2012 educational article explained that in autoimmune inflammatory conditions, IL-6 promotes antibody production, drives CRP levels, and has other pathological roles.
