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The (C;C) genotype is linked to reduced UGT1A1 activity, and increased Bilirubin, except in people of African origin for whom the T allele is a risk factor for breast cancer.
[PMID 17424838] [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].
[PMID 17498780] The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers.
[PMID 18992148] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
[PMID 19267064] [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer].
[PMID 19482841] Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.
[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 24865931] Combined effects of the UGT1A1 and OATP2 gene polymorphisms as major risk factor for unconjugated hyperbilirubinemia in Indian neonates
|Gene||UGT1A5 UGT1A9 UGT1A3 UGT1A6 UGT1A4 LOC100286922 UGT1A8 UGT1A10 LOC101927831 UGT1A7|
|CLNDBN||Gilbert syndrome, susceptibility to|
|CLNSRC||ClinVar OMIM Allelic Variant|