From SNPedia
| ? | (A;A) (A;C) (C;C) | 28 |
|---|
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[PMID 17658295] obstructive sleep apnea rs405509
[PMID 19172988] Significant Alzheimer's disease associations with were found for rs449647(A;A) and rs405509(G;G) genotypes (positive), and rs449647(A;T) and rs405509(T;T)
[PMID 19282863] Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
[PMID 19384966] Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene
[PMID 19808960] Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk
| PharmGKB | PA162411184 |
| Name | APOE:-219G-->T |
| Annotation | A study in 2150 Japanese individuals with metabolic syndrome, including 411 subjects with chronic kidney disease (CKD) and 1739 controls found that the -219G-->T SNP in APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome. |
| Gene | TOMM40, APOE, APOC1 |
| Featue | |
| Evidence | PubMed ID:19056482 |
| Drugs | |
| Diseases | Kidney Diseases, metabolic syndrome |
| Curation Level | Curated |
[PMID 21263195] An APOE Haplotype Associated with Decreased ?4 Expression Increases the Risk of Late Onset Alzheimer's Disease
[PMID 21266206] Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake - The Cardiovascular Risk in Young Finns Study
[PMID 22028770] APOE Genotype-Function Relationship: Evidence of -491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk
