Rs3842787

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Orientationplus
is asnp
is mentioned by
dbSNPrs3842787
PheGenIrs3842787
nextbiors3842787
hapmaprs3842787
1000 genomesrs3842787
hgdprs3842787
ensemblrs3842787
gopubmedrs3842787
geneviewrs3842787
scholarrs3842787
googlers3842787
pharmgkbrs3842787
gwascentralrs3842787
openSNPrs3842787
23andMers3842787
23andMe allrs3842787
SNP Nexus

SNPshotrs3842787
SNPdbers3842787
MSV3drs3842787
GenePTGS1
Chromosome9
Orientationplus
GMAF0.06841
Position122371228
ReferenceGRCh38 38.1/141
Max Magnitude3
Geno Mag Summary
(C;C) 0 normal
(C;T) 2 Higher risk of bleeding during coronary angiography
(T;T) 3 Higher risk of bleeding during coronary angiography
rs3842787, also known as 50C>T, is a SNP in the signal peptide region of the cyclooxygenase-1 PTGS1 gene.

A study of 696 European patients undergoing elective diagnostic coronary angiographies (CAGs) because of suspected or proven stable coronary artery disease found that 23 experienced bleeding, perhaps the most common complication of this type of invasive coronary procedure. After controlling for various variables (especially gender), two co-inherited SNPs, rs10306114 and rs3842787, were found to be associated with higher risk for bleeding in otherwise low risk patients who (i) did undergo percutaneous coronary intervention and (ii) did not take clopidogrel. Having the less common haplotype (rs10306114(G) and/or rs3842787(T)) increases the bleeding risk upon CAG ~12 fold (p = 0.012).[PMID 20691446]

? (C;C) (C;T) (T;T) 28


[PMID 19786296] Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction


[PMID 20214591] Pharmacogenomics in aspirin intolerance




[PMID 17355643OA-icon.png] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.


[PMID 17495879OA-icon.png] Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.


[PMID 18992148OA-icon.png] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.


[PMID 19046748OA-icon.png] Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.


GET Evidence
PTGS1-P17L
aa_change Pro17Leu
aa_change_short P17L
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0900893
summary



[PMID 23765972] Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population


[PMID 23029430OA-icon.png] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.