From SNPedia
| Geno
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Mag
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Summary
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| (C;C)
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2.1
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2-3x higher risk for cardiovascular events, which can be lowered by aspirin
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| (C;T)
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2
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2-3x higher risk for cardiovascular events, which can be lowered by aspirin
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| (T;T)
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0
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normal
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| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
, also known as I4399M or Ile4399Met, is a SNP in the apolipoprotein(A)
LPA gene that has been reported to be associated with elevated plasma lipoprotein(a) [Lp(a)] and increased cardiovascular risk, and in particular,
coronary artery disease.
In one study, 25,131 initially healthy Caucasian participants in the Women's Health Study were followed for ~10 years. rs3798220(C) allele carriers (3.7%) in the placebo (i.e. not receiving aspirin) group had a 2x higher risk of major cardiovascular events than non-carriers (age-adjusted hazard ratio (HR) of 2.21, CI: 1.39-3.52). Among rs3798220(C) carriers, the risk was reduced more than twofold by aspirin: for aspirin compared with placebo the age-adjusted HR was 0.44 (CI: 0.20-0.94). The risk was not significantly reduced among non-carriers (age-adjusted HR=0.91, CI: 0.77-1.08). This interaction between carrier status and aspirin allocation was significant (P=0.048). In summary, rs3798220(C) carriers had higher plasma lipoprotein(a) and had double the risk of cardiovascular events, but also benefited more from taking aspirin.[PMID 18775538]
In another study, compared with noncarriers, carriers of the 4399M risk allele (2.7% of controls) had an adjusted odds ratio for severe CAD of 3.14 (CI: 1.51 to 6.56), and had 5-fold higher median plasma lipoprotein(a) levels (P=0.003), leading to the conclusion that the LPA I4399M SNP is associated with severe CAD and plasma lipoprotein(a) levels.[PMID 17569884]
[PMID 20032323] Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
celera says rs3798220 is an independent predictor of risk for
Carriers of the rs3798220(C) have higher levels of plasma Lp(a).
[PMID 20605575] Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus
| GWAS snp
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| PMID
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[PMID 21378990]
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| Trait
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| Title
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
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| Risk Allele
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C
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| P-val
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3E-11
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| Odds Ratio
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1.5100 [1.33-1.70]
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[PMID 22192511] KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly
