From SNPedia
rs3761847, a SNP located between two genes associated with chronic inflammation (
TRAF1 and
C5), is associated with increased risk of anti CCP-positive
rheumatoid arthritis.
The risk allele is (G); the odds ratio reported is 1.32 (95% confidence interval, 1.23 to 1.42; P=4x10-14) [PMID 17804836].
[PMID 19116907] rs3761847(G;G) associated with an increased risk of death (hazard ratio 3.96 [95% confidence interval 1.24-12.6], P = 0.020) as compared with (A;A) homozygote status. The excess mortality was attributed to deaths due to malignancies and sepsis but not cardiovascular disease (CVD).
| ? | (A;A) (A;G) (G;G) |
|---|
 |
[PMID 19401279] Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
[PMID 19565500] Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
Related to TNF RECEPTOR-ASSOCIATED FACTOR 1; TRAF1
according to
omim 601711. See
also
[PMID 19714643] TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
| PharmGKB | PA162356690 |
| Name | |
| Annotation | GWAS Results: TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study (Initial Sample Size: 1,493 cases, 1,831 controls; Replication Sample Size: 1,053 cases, 1,858 controls; Risk Allele: rs3761847-G). |
| Gene | TRAF1 |
| Featue | |
| Evidence | PubMed ID:17804836; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Arthritis, Rheumatoid |
| Curation Level | Non-Curated |
[PMID 19336421] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
