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rs363039

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;G)
(C;C)
(T;T) 0
Make rs363039(C;T)
ReferenceGRCh38 38.1/142
Chromosome20
Position10239848
GeneSNAP25
is asnp
is mentioned by
dbSNPrs363039
dbSNP (classic)rs363039
ClinGenrs363039
ebirs363039
HLIrs363039
Exacrs363039
Gnomadrs363039
Varsomers363039
LitVarrs363039
Maprs363039
PheGenIrs363039
Biobankrs363039
1000 genomesrs363039
hgdprs363039
ensemblrs363039
geneviewrs363039
scholarrs363039
googlers363039
pharmgkbrs363039
gwascentralrs363039
openSNPrs363039
23andMers363039
SNPshotrs363039
SNPdbers363039
MSV3drs363039
GWAS Ctlgrs363039
GMAF0.4467
Max Magnitude0
? (C;C) (C;T) (T;T) 28


This is one of four SNPs in the first intron of the SNAP25 gene that have been correlated with increased intelligence based on studies of ~300 Caucasian subjects.[PMID 16801949]

In orientation to the dbSNP entry for this SNP, rather than as published, the (C;C) genotype averages ~2 PIQ points higher than the (C;T) genotype, which averages 2 PIQ points higher than the (T;T) genotype.[PMID 16801949]

For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). [PMID 17908175]


[PMID 20950795] The SNAP25 Gene Is Linked to Working Memory Capacity and Maturation of the Posterior Cingulate Cortex During Childhood


[PMID 22193912] Variants in SNAP25 are targets of natural selection and influence verbal performances in women


[PMID 23593184OA-icon.png] DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex.


[PMID 25445064] Synaptosome-related (SNARE) genes and their interactions contribute to the susceptibility and working memory of attention-deficit/hyperactivity disorder in males