Rs34778348
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs34778348 |
| hapmap | rs34778348 |
| hgdp | rs34778348 |
| ensembl | rs34778348 |
| gopubmed | rs34778348 |
| scholar | rs34778348 |
| rs34778348 | |
| pharmgkb | rs34778348 |
| hgvbaseg2p | rs34778348 |
| medrefsnp | rs34778348 |
| 23andMe | rs34778348 |
| SNP Nexus |
| Gene | LRRK2 |
| Chromosome | 12 |
| Orientation | plus |
| Position | 39043594 |
| Genotype | Effect |
|---|---|
| rs34778348(A;A) | 2.1x increased risk for Parkinson's disease |
| rs34778348(A;G) | 2.1x increased risk for Parkinson's disease |
| rs34778348(G;G) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs34778348(A;A) | 2.1x increased risk for Parkinson's disease | |
| Rs34778348(A;G) | 2.1x increased risk for Parkinson's disease | |
| Rs34778348(G;G) | normal |
In perfect contrast to another SNP also within the LRRK2 gene, rs34637584, this SNP, rs34778348, is not found in Caucasian populations but is found in Asian populations.
A case-control study of 989 Chinese subjects concluded that the odds ratio for Parkinson's disease was 2.1 for rs34778348(A) carriers (CI: 1.1-3.9, p = 0.014). This SNP was estimated to account for 4% of all Parkinson cases in this population.[PMID 17019612]
| ? | (A;A) (A;G) (G;G) |
|---|---|
|
| |
[PMID 19854095] The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population
