From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
|
| (C;T)
|
1.3
|
1.3x higher risk for endometrial cancer (in Chinese women)
|
| (T;C)
|
|
|
| (T;T)
|
1.3
|
1.2x higher breast cancer risk; 1.3x higher risk for endometrial cancer (in Chinese women)
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
shows an association with
breast cancer in a British study involving ~2300 patients. The odds ratio for the (T;T) vs (C;C) homozygotes is 1.22 (CI: 1.02-1.47, p=0.013).[
PMID 18174243]
[PMID 15026335] found a significant association between rs34330 (-79C/T) and prostate cancer
[PMID 21454826] found higher odds for endometrial cancer among 1,200+ Chinese patients associated with rs34330, with an odds ratio of 1.33 (CI: 1.06-1.66) and 1.51 (CI: 1.16-1.94) for the (C;T) and (T;T) genotypes, respectively, compared with the (C;C) genotype.
see also omim 176807
| OMIM | 600778 |
| Desc | CYCLIN-DEPENDENT KINASE INHIBITOR 1B; CDKN1B |
| Variant | |
| Related | also |
[PMID 20075119] Allelic variant at -79 (C>T) in CDKNIB (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels
