From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2.5
|
significantly increased risk for substance use disorders
|
| (A;C)
|
|
normal
|
| (C;C)
|
0
|
normal
|
| ? | (A;A) (A;C) (C;C) | 28 |
|---|
 |
is a SNP, also known as Pro129Thr, in the fatty acid amide hydrolase
FAAH gene, which has shown associations with some substance use disorders.
rs324420(C) encodes the more common Pro, while the (A) allele encodes the Thr.
Among 80 individuals with drug abuse or alcoholism and over 1,000 controls, the odds ratio for risk of problem drug or alcohol use among rs32440(A;A) individuals was 4.5 (CI: 2.2 - 8.4); the odds ratio for risk of street drug use was 2.2 (CI: 1.3–3.7); and the odds ratio for risk of combined street drug use and problem drug/alcohol use was 4.9 (CI: 2.5–9.7)[PMID 12060782]
When this study was pooled with the results of another study of 249 subjects with documented multiple different drug addictions compared to drug free individuals of the same ethnic backgrounds, the results were consistent and even more significant (p = 0.00003). Risk for drug dependence (and drug abuse was associated with rs324420(A;A) homozygotes. [PMID 16972078]
In a study of 40 daily marijuana users who abstained for 24 h and were then presented with a cue-elicited craving paradigm, followed by smoking a marijuana cigarette, rs324420(A) was significantly associated with changes in withdrawal after abstinence and with happiness after smoking marijuana, but was not associated with changes in heart rate after smoking or with changes in craving or other acute effects.[PMID 19002671]
[PMID 19958092] Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent
[PMID 20044928] Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
[PMID 20010552] Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues
| PharmGKB | PA165111693 |
| Name | FAAH:385C>A, FAAH:Pro129Thr |
| Annotation | Risk or phenotype-associated allele: A Phenotype: Homozygous AA individuals were less likely to be cannabinoid dependent. Study size: 749 Study population/ethnicity: Healthy Caucasian Volunteers; Toronto, Canada Significance metric(s): p < 0.05 Type of association: CO |
| Gene | FAAH |
| Featue | |
| Evidence | PubMed ID:17290447 |
| Drugs | |
| Diseases | Substance-Related Disorders |
| Curation Level | Curated |
| PharmGKB | PA165111626 |
| Name | C385A, Pro129Thr |
| Annotation | Risk or phenotype-associated allele: A. Phenotype: This nonsynonymous coding variant is associated with increased BMI, increased triglycerides, and reduced levels of high-density lipoprotein cholesterol. This is independent of insulin response. Study size: 1644 individuals from 261 families of northern european ancestry. Study population/ethnicity: northern european. Significance metric(s): BMI (P=0.042); fasting TG (p=0.022); HDL (p = 0.007). Type of association: GN; CO |
| Gene | FAAH |
| Featue | |
| Evidence | PubMed ID:19958092 |
| Drugs | |
| Diseases | Obesity |
| Curation Level | Curated |
[PMID 22068813] The Fatty Acid Amide Hydrolase (FAAH) Gene Variant rs324420 AA/AC is not Associated with Weight Loss in a 1-Year Lifestyle Intervention for Obese Children and Adolescents
