From SNPedia
| Geno
|
Mag
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Summary
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| (A;A)
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lower risk for breast, ovarian cancer
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| (A;G)
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lower risk for breast, ovarian cancer
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| (G;G)
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0
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normal risk
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| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
, a relatively rare SNP also known as Arg188His located in the DNA-repair gene
XRCC2, is associated with a lowered risk for
breast cancer based on a study of 1,100 Cypriot women. The odds ratio for the His-encoding
rs3218536(A) allele carriers is homozygote is 0.79, CI: 0.62-1.00, p=0.05.[
PMID 18188695]
rs3218536(A) carriers also appear to be at lower risk for epithelial ovarian cancer. In a study of ~1,600 cases, the odds ratio for rs3218536(A;G) heterozygotes was 0.8 (CI: 0.7-1.0) and for the (quite rare) rs3218536(A;A) homozygotes 0.3 (0.1-0.9).[PMID 15924337]
[PMID 19690184] Genetic Variants in XRCC2: New Insights Into Colorectal Cancer Tumorigenesis
[PMID 20127279] XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects
[PMID 21632523] A role for XRCC2 gene polymorphisms in breast cancer risk and survival
[PMID 22481871] Assessment of genetic mutations in the XRCC2 coding region by high resolution melting curve analysis and the risk of differentiated thyroid carcinoma in Iran
