From SNPedia
rs3218536, a relatively rare SNP also known as Arg188His located in the DNA-repair gene XRCC2, is associated with a lowered risk for breast cancer based on a study of 1,100 Cypriot women. The odds ratio for the His-encoding rs3218536(A) allele carriers is homozygote is 0.79, CI: 0.62-1.00, p=0.05.[PMID 18188695]
rs3218536(A) carriers also appear to be at lower risk for epithelial ovarian cancer. In a study of ~1,600 cases, the odds ratio for rs3218536(A;G) heterozygotes was 0.8 (CI: 0.7-1.0) and for the (quite rare) rs3218536(A;A) homozygotes 0.3 (0.1-0.9).[PMID 15924337]
| ? | (A;A) (A;G) (G;G) |
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[PMID 19690184] Genetic Variants in XRCC2: New Insights Into Colorectal Cancer Tumorigenesis
[PMID 20127279] XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects
