rs3132293

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)		normal
(A;G)		decreased risk of Alzheimer's disease
(G;G)		decreased risk of Alzheimer's disease

Reference

GRCh38 38.1/141

Chromosome

9

Position

134433976

Gene

RXRA

is a	snp
is	mentioned by
dbSNP	rs3132293
dbSNP (classic)	rs3132293
ClinGen	rs3132293
ebi	rs3132293
HLI	rs3132293
Exac	rs3132293
Gnomad	rs3132293
Varsome	rs3132293
LitVar	rs3132293
Map	rs3132293
PheGenI	rs3132293
Biobank	rs3132293
1000 genomes	rs3132293
hgdp	rs3132293
ensembl	rs3132293
geneview	rs3132293
scholar	rs3132293
google	rs3132293
pharmgkb	rs3132293
gwascentral	rs3132293
openSNP	rs3132293
23andMe	rs3132293
SNPshot	rs3132293
SNPdbe	rs3132293
MSV3d	rs3132293
GWAS Ctlg	rs3132293

GMAF

0.1882

Max Magnitude

0

A screen of SNPs in the RXRA gene in 405 Alzheimer's disease patients (mean age 74 +/- 9 years) suggests that the rs3132293(G) allele (in dbSNP orientation) is associated with lower risk for the disease.[PMID 18544046]

However, it should be noted that (1) this allele is quite common, (2) there was a significant difference in the % of females (79%) in the patient population compared to the control population (57%), and (3) the magnitude of associated changes in cerebral cholesterol is not high.

[PMID 19374686] RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism