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Rs3025039

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 2 2.6x increased risk for ARMD in a Taiwanese population
(T;T) 2 2.6x increased risk for ARMD in a Taiwanese population
ReferenceGRCh38 38.1/141
Chromosome6
Position43784799
GeneVEGFA
is asnp
is mentioned by
dbSNPrs3025039
ebirs3025039
Exacrs3025039
PheGenIrs3025039
hapmaprs3025039
1000 genomesrs3025039
hgdprs3025039
ensemblrs3025039
gopubmedrs3025039
geneviewrs3025039
scholarrs3025039
googlers3025039
pharmgkbrs3025039
gwascentralrs3025039
openSNPrs3025039
23andMers3025039
23andMe allrs3025039
SNP Nexus

SNPshotrs3025039
SNPdbers3025039
MSV3drs3025039
GWAS Ctlgrs3025039
GMAF0.1492
Max Magnitude2
rs3025039, also known as the +936C/T SNP in the VEGFA gene, has been associated with age-related macular degeneration (ARMD).

A study of 190 Taiwanese patients with late wet age related macular degeneration found that the rs3025039(T) allele was associated with increased risk, with an odds ratio of 2.61 (CI: 1.68 to 4.07, p = 1.45 x 10e-5).[PMID 18378209]

Note that this association may be completely due to the tight linkage (D' = 0.99) between this SNP and rs1061170, which has been reported by numerous studies to be associated with ARMD.


[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer

[PMID 19875757] Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy



[PMID 20082870] A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation


[PMID 20847577] Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort

C->T was associated with increased risk for altitude sickness. [PMID 21242666] Polymorphisms of Hypoxia-Related Genes in Subjects Susceptible to Acute Mountain Sickness


[PMID 22129133] VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma


[PMID 22315135] The single-nucleotide polymorphisms +936 C/T VEGF and -710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population


[PMID 22439647OA-icon.png] The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study


[PMID 22162628OA-icon.png] Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes


[PMID 21905000] Disruption of vascular homeostasis in Kawasaki Disease patients: Involvement of vascular endothelial growth factor and angiopoietins.


[PMID 22818823] Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients

[PMID 15338501] Vascular endothelial growth factor gene polymorphisms in Behcet's disease.

[PMID 16613616OA-icon.png] Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

[PMID 16645995] Vascular endothelial growth factor gene haplotypes in Kawasaki disease.

[PMID 17204151OA-icon.png] VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.

[PMID 17319747OA-icon.png] Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

[PMID 17601350OA-icon.png] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 17983459] Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.

[PMID 18281657] VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.

[PMID 18650217] Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18780893OA-icon.png] Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 19041064] Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.

[PMID 19089753] Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.

[PMID 19196101] Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan.

[PMID 19372140OA-icon.png] EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis.

[PMID 19438866OA-icon.png] Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.

[PMID 19496079] Effect of polymorphisms in the 3' untranslated region (3'-UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan.

[PMID 19566948OA-icon.png] Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

[PMID 19584152OA-icon.png] Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.

[PMID 19603096OA-icon.png] An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.

[PMID 19628492] Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy.

[PMID 19755511OA-icon.png] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

[PMID 19787077OA-icon.png] Association of vascular endothelial growth factor polymorphisms with asthma in Tunisian children.

[PMID 19835575OA-icon.png] The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

[PMID 20019880OA-icon.png] Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20540786OA-icon.png] The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients.

[PMID 21080079] Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.

[PMID 21245770] Vascular endothelial growth factor gene polymorphisms and rheumatoid arthritis.

[PMID 21347390OA-icon.png] Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

[PMID 21362767] Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis.

[PMID 21982816] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.

[PMID 22139971] Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.

[PMID 22320189OA-icon.png] Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

[PMID 22429695] Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking.

[PMID 22521084] Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration.


[PMID 23073296] VEGF Polymorphisms are not associated with an Increased Risk of Developing Renal Cell Carcinoma in Spanish population


[PMID 23211130] Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage


[PMID 22776467] Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes


[PMID 23631762OA-icon.png] Genotyping analysis and 18FDG uptake in breast cancer patients: a preliminary research


[PMID 23848209] Vascular endothelial growth factor A (VEGFA) polymorphisms in Chinese patients with rheumatoid arthritis


[PMID 23880405] Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population


[PMID 24353087] Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer


[PMID 22491902] The interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth.


[PMID 22729570] AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.


[PMID 22925497] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.


[PMID 23061744] Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis.


[PMID 23102494] Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka.


[PMID 23264084] Positive association of the vascular endothelial growth factor-A +405 GG genotype and poor survival in stage I-II gastric cancer in the Northern Chinese population.


[PMID 23545315] Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.


[PMID 23586368] Vascular endothelial growth factor 936 c>T polymorphism increased oral cancer risk: evidence from a meta-analysis.


[PMID 23625573] A common and functional gene variant in the vascular endothelial growth factor a predicts clinical outcome in early-stage breast cancer.


[PMID 23644986] Genetic polymorphisms of vascular endothelial growth factor and risk for retinopathy of prematurity in South of Iran.


[PMID 24868559OA-icon.png] The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies


[PMID 24940484OA-icon.png] Association between vascular endothelial growth factor gene polymorphisms and bladder cancer risk


[PMID 25713884] Serum cytokine levels in patients with colorectal cancers according to tumor stages and VEGF gene polymorphism


[PMID 25894981] Genetic Variations of VEGF Gene Were Associated with Tetralogy of Fallot Risk in a Chinese Han Population


[PMID 26075076OA-icon.png] Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis


[PMID 26264619] Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers


[PMID 24971577OA-icon.png] Vascular endothelial growth factor A (VEGFA) gene polymorphisms have an impact on survival in a subgroup of indolent patients with chronic lymphocytic leukemia


[PMID 25714003] Association of VEGFA gene polymorphisms and VEGFA plasma levels with spontaneous preterm birth


[PMID 27116510] Effect of Risk Alleles in CFH, C3, and VEGFA on the Response to Intravitreal Bevacizumab in Tunisian Patients with Neovascular Age-related Macular Degeneration.