|(G;G)||Duffy-negative: increased odds of HIV infection upon exposure, but slowed disease progression if infected|
The rs2814778 (G) allele is associated with African populations, while rs2814778 (A) is associated with European populations and southwestern Native American populations.
[PMID 19180233] rs2814778(G;G) protect against Plasmodium vivax malaria and predicts of white blood cell and neutrophil count
23andMe blog discussion
|Title||Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.|
|Odds Ratio||None None|
[PMID 22207676] The association between a Darc gene polymorphism and clinical outcomes in African Americans with acute lung injury
|Title||Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.|
|Odds Ratio||1.3500 None|
[PMID 15660291] Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study.
[PMID 16685648] Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
[PMID 17069770] Personality traits of agreeableness and extraversion are associated with ADH4 variation.
[PMID 17185388] Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.
[PMID 18179887] Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies.
[PMID 18248572] Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease.
[PMID 18654799] Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease.
[PMID 18710383] Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean.
[PMID 18827265] Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations.
[PMID 19369910] The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.
[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight.
[PMID 19737746] Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.
[PMID 19758966] Ethnic and genetic causes of neutropenia: clinical and therapeutic implications.
[PMID 20021678] Evaluation of self-reported ethnicity in a case-control population: the stroke prevention in young women study.
[PMID 21257350] DNA-based methods in the immunohematology reference laboratory.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
|Disease||DUFFY BLOOD GROUP SYSTEM PLASMODIUM VIVAX White blood cell count quantitative trait locus 1|
|CLNDBN||DUFFY BLOOD GROUP SYSTEM, FY(a-b-) PHENOTYPE PLASMODIUM VIVAX, RESISTANCE TO White blood cell count quantitative trait locus 1|
|CLNSRC||OMIM Allelic Variant dbRBC - Blood Group Antigen Gene Mutation Database|
|CLNACC||RCV000000006.3, RCV000000007.3, RCV000000008.2,|